Publication:
Short and oral antimicrobial therapy for diabetic foot infection: a narrative review of current knowledge

dc.contributor.coauthorMaurer, S.M.
dc.contributor.coauthorHepp, Z.S.
dc.contributor.coauthorMcCallin, S.
dc.contributor.coauthorWaibel, F.W.A.
dc.contributor.coauthorRomero, F.C.
dc.contributor.coauthorLipsky, B.A.
dc.contributor.coauthorUçkay, I.
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.kuauthorZorman, Yılmaz
dc.contributor.kuauthorZorman, Yılmaz
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.date.accessioned2024-11-09T12:00:27Z
dc.date.issued2022
dc.description.abstractDiabetic foot infection is a frequent complication in long-standing diabetes mellitus. For antimicrobial therapy of this infection, both the optimal duration and the route of administration are often based more on expert opinion than on published evidence. We reviewed the scientific literature, specifically seeking prospective trials, and aimed at addressing two clinical issues: (1) shortening the currently recommended antibiotic duration and (2) using oral (rather than parenteral) therapy, especially after the patient has undergone debridement and revascularization. We also reviewed some older key articles that are critical to our understanding of the treatment of these infections, particularly with respect to diabetic foot osteomyelitis. Our conclusion is that the maximum duration of antibiotic therapy for osteomyelitis should be no more than to 4-6 weeks and might even be shorter in selected cases. In the future, in addition to conducting randomized trials and propagating national and international guidance, we should also explore innovative strategies, such as intraosseous antibiotic agents and bacteriophages.
dc.description.fulltextYES
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume7
dc.identifier.doi10.5194/jbji-7-61-2022
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03680
dc.identifier.issn2206-3552
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85127827745
dc.identifier.urihttps://hdl.handle.net/20.500.14288/945
dc.keywordsDiabetic foot
dc.keywordsOsteomyelitis
dc.keywordsInfection
dc.language.isoeng
dc.publisherCopernicus Publications
dc.relation.grantnoNA
dc.relation.ispartofJournal of Bone and Joint Infection
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10533
dc.subjectMedicine
dc.titleShort and oral antimicrobial therapy for diabetic foot infection: a narrative review of current knowledge
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorZorman, Yılmaz
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
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