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A novel method for PEGylation of chitosan nanoparticles through photopolymerization

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dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.kuauthorBozüyük, Uğur
dc.contributor.kuauthorDoğan, Nihal Olcay
dc.contributor.kuauthorGökulu, İpek Simay
dc.contributor.kuauthorKızılel, Seda
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.date.accessioned2024-11-09T11:39:53Z
dc.date.issued2019
dc.description.abstractAn ultrafast and convenient method for PEGylation of chitosan nanoparticles has been established through a photopolymerization reaction between the acrylate groups of PEG and methacrylated-chitosan nanoparticles. The nanoparticle characteristics under physiological pH conditions were optimized through altered PEG chain length, concentration and duration of UV exposure. The method developed here has potential for clinical translation of chitosan nanoparticles. It also allows for the scalable and fast synthesis of nanoparticles with colloidal stability.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue25
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuEU - TÜBİTAK
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TÜBİTAK)
dc.description.sponsorshipEuropean Union (European Union)
dc.description.sponsorshipHorizon 2020
dc.description.sponsorshipEuropean Union COST Action
dc.description.sponsorshipPresidency of Turkey
dc.description.sponsorshipPresidency of Strategy and Budget
dc.description.versionPublisher version
dc.description.volume9
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR01649
dc.identifier.issn2046-2069
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85065639432
dc.identifier.urihttps://hdl.handle.net/20.500.14288/168
dc.identifier.wos468640100008
dc.keywordsDrug-delivery
dc.keywordsHydrogels
dc.keywordsChemistry
dc.keywordsChitin
dc.language.isoeng
dc.publisherRoyal Society of Chemistry (RSC)
dc.relation.grantnoCA15216
dc.relation.grantno116M995
dc.relation.ispartofRSC Advances
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8256
dc.subjectChemistry
dc.titleA novel method for PEGylation of chitosan nanoparticles through photopolymerization
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorBozüyük, Uğur
local.contributor.kuauthorGökulu, İpek Simay
local.contributor.kuauthorDoğan, Nihal Olcay
local.contributor.kuauthorKızılel, Seda
local.publication.orgunit1College of Engineering
local.publication.orgunit2Department of Chemical and Biological Engineering
relation.isOrgUnitOfPublicationc747a256-6e0c-4969-b1bf-3b9f2f674289
relation.isOrgUnitOfPublication.latestForDiscoveryc747a256-6e0c-4969-b1bf-3b9f2f674289
relation.isParentOrgUnitOfPublication8e756b23-2d4a-4ce8-b1b3-62c794a8c164
relation.isParentOrgUnitOfPublication.latestForDiscovery8e756b23-2d4a-4ce8-b1b3-62c794a8c164

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