Publication:
Baseline hemoglobin <11.0 g/dL has stronger prognostic value than anemia status in nasopharynx cancers treated with chemoradiotherapy

dc.contributor.coauthorTopkan, Erkan
dc.contributor.coauthorEkici, Nur Yücel
dc.contributor.coauthorÖzdemir, Yurday
dc.contributor.coauthorBesen, Ali Ayberk
dc.contributor.coauthorYıldırım, Berna Akkuş
dc.contributor.coauthorMertsoylu, Hüseyin
dc.contributor.kuauthorSezen, Duygu
dc.contributor.kuauthorSelek, Uğur
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileFaculty Member
dc.contributor.yokidN/A
dc.contributor.yokid27211
dc.date.accessioned2024-11-09T13:07:11Z
dc.date.issued2019
dc.description.abstractBackground: to retrospectively investigate the influence of pretreatment anemia and hemoglobin levels on the survival of nasopharyngeal carcinoma patients treated with concurrent chemoradiotherapy (C-CRT). Methods: a total of 149 nasopharyngeal carcinoma patients who received C-CRT were included. All patients had received 70 Gy to the primary tumor plus the involved lymph nodes, and 59.4 Gy and 54 Gy to the intermediate- and low-risk neck regions concurrent with 1-3 cycles of cisplatin. Patients were dichotomized into non-anemic and anemic (hemoglobin <12 g/dL (women) or <13 g/dL (men)) groups according to their pre-treatment hemoglobin measures. Receiver operating characteristic (ROC) curve analysis was utilized for accessibility of a pre-treatment hemoglobin cut-off that impacts outcomes. Potential interactions between baseline anemia status and hemoglobin measures and overall survival, locoregional progression-free survival (LRPFS), and progression-free survival were assessed. Results: Anemia was evident in 36 patients (24.1%), which was related to significantly shorter overall survival (P=0.007), LRPFS (P<0.021), and progression-free survival (P=0.003) times; all three endpoints retained significance in multivariate analyses (P<0.05, for each). A baseline hemoglobin value of 11.0 g/dL exhibited significant association with outcomes in ROC curve analysis: hemoglobin <11.0 g/dL (N=26) was linked with shorter median overall survival (P<0.001), LRPFS (P=0.004), and progression-free survival (P<0.001) times, which also retained significance for all three endpoints in multivariate analyses and suggested a stronger prognostic worth for the hemoglobin Conclusion: pre-C-CRT hemoglobin <11.0 g/dL has a stronger prognostic worth than the anemia status with regard to LRPFS, progression-free survival, and overall survival for nasopharyngeal carcinoma patients.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.issue2
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume34
dc.formatpdf
dc.identifier.doi10.1177/1724600818821688
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR01740
dc.identifier.issn0393-6155
dc.identifier.linkhttps://doi.org/10.1177/1724600818821688
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85067842519
dc.identifier.urihttps://hdl.handle.net/20.500.14288/2562
dc.identifier.wos473034700006
dc.keywordsAnemia
dc.keywordsConcurrent chemoradiotherapy
dc.keywordsHemoglobin
dc.keywordsNasopharyngeal carcinoma
dc.keywordsPrognosis
dc.languageEnglish
dc.publisherSage
dc.relation.grantnoNA
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8378
dc.sourceInternational Journal of Biological Markers
dc.subjectMedicine
dc.subjectBiotechnology and applied microbiology
dc.subjectOncology
dc.titleBaseline hemoglobin <11.0 g/dL has stronger prognostic value than anemia status in nasopharynx cancers treated with chemoradiotherapy
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authoridN/A
local.contributor.authorid0000-0001-8087-3140
local.contributor.kuauthorSezen, Duygu
local.contributor.kuauthorSelek, Uğur
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine

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