Publication:
A case of radiologically isolated syndrome developing Balo's concentric sclerosis lesions on long-term follow-up

dc.contributor.coauthorDanyeli, Ayça Ersen
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.kuauthorAltıntaş, Ayşe
dc.contributor.kuauthorÇalışkan, İlay
dc.contributor.kuauthorPeker, Selçuk
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileFaculty Member
dc.contributor.yokid11611
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokid11480
dc.date.accessioned2024-11-09T12:29:57Z
dc.date.issued2022
dc.description.abstractBackground; Radiologically Isolated Syndrome (RIS) depicts a clinical scenario with multiple sclerosis (MS)-like magnetic resonance imaging (MRI) findings in individuals without clinical features of a demyelinating bout. Balo’s concentric sclerosis (BCS) on the other hand, is a variant of MS characterized by concentrically layered white mater demyelinating lesions. Case presentation: a 49-year-old male with an incidental brain lesion on MRI underwent a stereotactic biopsy and diagnosed as a demyelinating process. He remained asymptomatic throughout the long term clinical and radiological follow-up. However, the patient developed new demyelinating lesions with some showing concentric layers of BCS. Conclusion:this is the first reported case; to our knowledge, whereby a pathologically verified RIS patient developed characteristic BCS lesions. Our case highlights the heterogeneity of RIS as a clinico-radiological entity, requiring further sub-classification of the spectrum for improved management
dc.description.fulltextYES
dc.description.indexedbyN/A
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume2
dc.formatpdf
dc.identifier.doi10.1016/j.nerep.2022.100093
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03858
dc.identifier.issn2667-257X
dc.identifier.linkhttps://doi.org/10.1016/j.nerep.2022.100093
dc.identifier.quartileN/A
dc.identifier.urihttps://hdl.handle.net/20.500.14288/1880
dc.keywordsRadiologically isolated syndrome
dc.keywordsBalo’s concentric sclerosis
dc.languageEnglish
dc.publisherElsevier
dc.relation.grantnoNA
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10724
dc.sourceNeuroimmunology Reports
dc.subjectMedicine
dc.titleA case of radiologically isolated syndrome developing Balo's concentric sclerosis lesions on long-term follow-up
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0002-8524-5087
local.contributor.authoridN/A
local.contributor.authoridN/A
local.contributor.authorid0000-0003-3057-3355
local.contributor.kuauthorAltıntaş, Ayşe
local.contributor.kuauthorÇalışkan, İlay
local.contributor.kuauthorAhmed, Said Salim
local.contributor.kuauthorPeker, Selçuk
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1Graduate School of Health Sciences
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2KUH (Koç University Hospital)
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