Publication: Expression of salivary LINC01206, LINC01209, LINC01994, and ABCC5-AS1 may serve as diagnostic tools in laryngeal cancer
dc.contributor.coauthor | Aktan, Çağdaş | |
dc.contributor.coauthor | Küçükaslan, Ali Şahin | |
dc.contributor.coauthor | Cengiz, A. Buğra | |
dc.contributor.coauthor | Demirci, Mehmet | |
dc.contributor.coauthor | Sunter, Volkan | |
dc.contributor.coauthor | Dalmızrak, Ayşegül | |
dc.contributor.coauthor | Ünlü, Özge | |
dc.contributor.coauthor | Yiğit, Özgür | |
dc.contributor.coauthor | Çakır, Burak Ömür | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Baygül, Arzu Eden | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T23:11:28Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Purpose of the Study: lncRNAs appear to act as an important epigenetic regulator of the immune response to bacterial infection in mammals. However, a lncRNA that only exhibits pathogenic or beneficial potential during infection has not yet been described. Moreover, it is still not fully known whether there are specific lncRNAs whose expression changes in response to a particular pathogen or whether lncRNAs are mainly involved in basic cellular immune responses to different stress stimuli. This study aims to assess association between salivary lncRNAs and salivary bacterial pathogens in laryngeal cancer patients. Methods: LINC01206, LINC01209, LINC01994, and ABCC5-AS1 were analyzed among 13 candidate lncRNAs in the saliva samples of 35 patients with laryngeal carcinoma and 25 healthy control. Both their expressions and the quantitative amount of oral bacteria members (Rothia mucilaginosa, Streptococcus spp., Prevotella oris, Veillonella dispar, Neisseria subflava, and Peptostreptococcus stomatis) were analyzed using qPCR. To determine whether these lncRNAs and bacterial pathogens are useful as diagnostic biomarkers, their association with clinicopathological and demographic characteristics was analyzed. Results: When the study group compared with the control group, expression of LINC01206, LINC01209, LINC01994, and ABCC5-AS1 were 2.84-fold, 2.33-fold, 4.46-fold, and 2.27-fold lower, respectively (p < 0.05). In terms of the amount of bacteria DNA in saliva, no significant difference was found between the laryngeal cancer and the control groups (p > 0.05). Conclusion: These results may provide novel insights into the molecular mechanism underlying laryngeal cancer and lncRNA/microbiome applications may constitute a new and alternative method to prevent development of laryngeal cancer in the future. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 29 | |
dc.identifier.doi | 10.1016/j.genrep.2022.101706 | |
dc.identifier.issn | 2452-0144 | |
dc.identifier.scopus | 2-s2.0-85141500692 | |
dc.identifier.uri | https://doi.org/10.1016/j.genrep.2022.101706 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/9650 | |
dc.identifier.wos | 965567200007 | |
dc.keywords | Bacteria | |
dc.keywords | Bioinformatics | |
dc.keywords | Head and neck cancer | |
dc.keywords | Laryngeal cancer | |
dc.keywords | LncRNA antiinfective agent | |
dc.keywords | Bacterial DNA | |
dc.keywords | Bacterial RNA | |
dc.keywords | Biological marker | |
dc.keywords | Chemokine | |
dc.keywords | Chemokine receptor | |
dc.keywords | Complementary DNA | |
dc.keywords | Cytokine | |
dc.keywords | Cytokine receptor | |
dc.keywords | Interferon | |
dc.keywords | Interferon receptor | |
dc.keywords | Long noncoding RNA ABCC5-AS1 | |
dc.keywords | Long noncoding RNA LINC01206 | |
dc.keywords | Long noncoding RNA LINC01209 | |
dc.keywords | Long noncoding RNA LINC01994 | |
dc.keywords | Long untranslated RNA | |
dc.keywords | Messenger RNA | |
dc.keywords | Multidrug resistance protein 5 | |
dc.keywords | RNA polymerase II | |
dc.keywords | Transcription factor | |
dc.keywords | Transforming growth factor beta | |
dc.keywords | Tumor marker | |
dc.keywords | Tumor necrosis factor | |
dc.keywords | Tumor necrosis factor receptor | |
dc.keywords | Unclassified drug | |
dc.keywords | Adult | |
dc.keywords | Antigen presentation | |
dc.keywords | Article | |
dc.keywords | BCR signaling | |
dc.keywords | Bioinformatics | |
dc.keywords | Cancer diagnosis | |
dc.keywords | Cancer immunology | |
dc.keywords | Cancer patient | |
dc.keywords | Chemical carcinogenesis | |
dc.keywords | Clinical article | |
dc.keywords | Clinical feature | |
dc.keywords | Computer model | |
dc.keywords | Controlled study | |
dc.keywords | Cycle threshold value | |
dc.keywords | Cytotoxicity | |
dc.keywords | Diagnostic accuracy | |
dc.keywords | Diagnostic test accuracy study | |
dc.keywords | Diagnostic value | |
dc.keywords | Down regulation | |
dc.keywords | Family history | |
dc.keywords | Female | |
dc.keywords | Functional enrichment analysis | |
dc.keywords | Head and neck squamous cell carcinoma | |
dc.keywords | Human | |
dc.keywords | Human tissue | |
dc.keywords | KEGG | |
dc.keywords | Larynx carcinoma | |
dc.keywords | Macromolecule | |
dc.keywords | Male | |
dc.keywords | Middle aged | |
dc.keywords | Molecular diagnosis | |
dc.keywords | Mouth flora | |
dc.keywords | Natural killer cell | |
dc.keywords | Neisseria | |
dc.keywords | Neisseria subflava | |
dc.keywords | Nonhuman | |
dc.keywords | Peptostreptococcus | |
dc.keywords | Peptostreptococcus stomatis | |
dc.keywords | Prevotella | |
dc.keywords | Prevotella oris | |
dc.keywords | Protein RNA binding | |
dc.keywords | Real time polymerase chain reaction | |
dc.keywords | Receiver operating characteristic | |
dc.keywords | RNA metabolism | |
dc.keywords | Rothia mucilaginosa | |
dc.keywords | Saliva level | |
dc.keywords | Sensitivity and specificity | |
dc.keywords | Streptococcus | |
dc.keywords | TCR signaling | |
dc.keywords | TGF beta signaling | |
dc.keywords | Transcription regulation | |
dc.keywords | Veillonella | |
dc.keywords | Veillonella dispar | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartof | Gene Reports | |
dc.subject | Genetics | |
dc.subject | Heredity | |
dc.title | Expression of salivary LINC01206, LINC01209, LINC01994, and ABCC5-AS1 may serve as diagnostic tools in laryngeal cancer | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Baygül, Arzu Eden | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
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