Publication:
Expression of salivary LINC01206, LINC01209, LINC01994, and ABCC5-AS1 may serve as diagnostic tools in laryngeal cancer

dc.contributor.coauthorAktan, Çağdaş
dc.contributor.coauthorKüçükaslan, Ali Şahin
dc.contributor.coauthorCengiz, A. Buğra
dc.contributor.coauthorDemirci, Mehmet
dc.contributor.coauthorSunter, Volkan
dc.contributor.coauthorDalmızrak, Ayşegül
dc.contributor.coauthorÜnlü, Özge
dc.contributor.coauthorYiğit, Özgür
dc.contributor.coauthorÇakır, Burak Ömür
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBaygül, Arzu Eden
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:11:28Z
dc.date.issued2022
dc.description.abstractPurpose of the Study: lncRNAs appear to act as an important epigenetic regulator of the immune response to bacterial infection in mammals. However, a lncRNA that only exhibits pathogenic or beneficial potential during infection has not yet been described. Moreover, it is still not fully known whether there are specific lncRNAs whose expression changes in response to a particular pathogen or whether lncRNAs are mainly involved in basic cellular immune responses to different stress stimuli. This study aims to assess association between salivary lncRNAs and salivary bacterial pathogens in laryngeal cancer patients. Methods: LINC01206, LINC01209, LINC01994, and ABCC5-AS1 were analyzed among 13 candidate lncRNAs in the saliva samples of 35 patients with laryngeal carcinoma and 25 healthy control. Both their expressions and the quantitative amount of oral bacteria members (Rothia mucilaginosa, Streptococcus spp., Prevotella oris, Veillonella dispar, Neisseria subflava, and Peptostreptococcus stomatis) were analyzed using qPCR. To determine whether these lncRNAs and bacterial pathogens are useful as diagnostic biomarkers, their association with clinicopathological and demographic characteristics was analyzed. Results: When the study group compared with the control group, expression of LINC01206, LINC01209, LINC01994, and ABCC5-AS1 were 2.84-fold, 2.33-fold, 4.46-fold, and 2.27-fold lower, respectively (p < 0.05). In terms of the amount of bacteria DNA in saliva, no significant difference was found between the laryngeal cancer and the control groups (p > 0.05). Conclusion: These results may provide novel insights into the molecular mechanism underlying laryngeal cancer and lncRNA/microbiome applications may constitute a new and alternative method to prevent development of laryngeal cancer in the future.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume29
dc.identifier.doi10.1016/j.genrep.2022.101706
dc.identifier.issn2452-0144
dc.identifier.scopus2-s2.0-85141500692
dc.identifier.urihttps://doi.org/10.1016/j.genrep.2022.101706
dc.identifier.urihttps://hdl.handle.net/20.500.14288/9650
dc.identifier.wos965567200007
dc.keywordsBacteria
dc.keywordsBioinformatics
dc.keywordsHead and neck cancer
dc.keywordsLaryngeal cancer
dc.keywordsLncRNA antiinfective agent
dc.keywordsBacterial DNA
dc.keywordsBacterial RNA
dc.keywordsBiological marker
dc.keywordsChemokine
dc.keywordsChemokine receptor
dc.keywordsComplementary DNA
dc.keywordsCytokine
dc.keywordsCytokine receptor
dc.keywordsInterferon
dc.keywordsInterferon receptor
dc.keywordsLong noncoding RNA ABCC5-AS1
dc.keywordsLong noncoding RNA LINC01206
dc.keywordsLong noncoding RNA LINC01209
dc.keywordsLong noncoding RNA LINC01994
dc.keywordsLong untranslated RNA
dc.keywordsMessenger RNA
dc.keywordsMultidrug resistance protein 5
dc.keywordsRNA polymerase II
dc.keywordsTranscription factor
dc.keywordsTransforming growth factor beta
dc.keywordsTumor marker
dc.keywordsTumor necrosis factor
dc.keywordsTumor necrosis factor receptor
dc.keywordsUnclassified drug
dc.keywordsAdult
dc.keywordsAntigen presentation
dc.keywordsArticle
dc.keywordsBCR signaling
dc.keywordsBioinformatics
dc.keywordsCancer diagnosis
dc.keywordsCancer immunology
dc.keywordsCancer patient
dc.keywordsChemical carcinogenesis
dc.keywordsClinical article
dc.keywordsClinical feature
dc.keywordsComputer model
dc.keywordsControlled study
dc.keywordsCycle threshold value
dc.keywordsCytotoxicity
dc.keywordsDiagnostic accuracy
dc.keywordsDiagnostic test accuracy study
dc.keywordsDiagnostic value
dc.keywordsDown regulation
dc.keywordsFamily history
dc.keywordsFemale
dc.keywordsFunctional enrichment analysis
dc.keywordsHead and neck squamous cell carcinoma
dc.keywordsHuman
dc.keywordsHuman tissue
dc.keywordsKEGG
dc.keywordsLarynx carcinoma
dc.keywordsMacromolecule
dc.keywordsMale
dc.keywordsMiddle aged
dc.keywordsMolecular diagnosis
dc.keywordsMouth flora
dc.keywordsNatural killer cell
dc.keywordsNeisseria
dc.keywordsNeisseria subflava
dc.keywordsNonhuman
dc.keywordsPeptostreptococcus
dc.keywordsPeptostreptococcus stomatis
dc.keywordsPrevotella
dc.keywordsPrevotella oris
dc.keywordsProtein RNA binding
dc.keywordsReal time polymerase chain reaction
dc.keywordsReceiver operating characteristic
dc.keywordsRNA metabolism
dc.keywordsRothia mucilaginosa
dc.keywordsSaliva level
dc.keywordsSensitivity and specificity
dc.keywordsStreptococcus
dc.keywordsTCR signaling
dc.keywordsTGF beta signaling
dc.keywordsTranscription regulation
dc.keywordsVeillonella
dc.keywordsVeillonella dispar
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofGene Reports
dc.subjectGenetics
dc.subjectHeredity
dc.titleExpression of salivary LINC01206, LINC01209, LINC01994, and ABCC5-AS1 may serve as diagnostic tools in laryngeal cancer
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorBaygül, Arzu Eden
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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