Publication:
A comparative study on thyroid function in alzheimer's disease: results from a Turkish multi-centre study

dc.contributor.coauthorYılmaz, Gökhan
dc.contributor.coauthorErbayraktar, Zübeyde
dc.contributor.coauthorEvlice, Ahmet
dc.contributor.coauthorGenç, Metin
dc.contributor.coauthorAras, Sevgi
dc.contributor.coauthorAvcı, Aslıhan
dc.contributor.coauthorYener, Görsev
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorUlusu, Nuriye Nuray
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-10T00:02:18Z
dc.date.issued2015
dc.description.abstractAlzheimer's disease is a very severe degenerative disease that affects brain function. Neuronal loss, accumulation of extracellular amyloid beta containing plaques and accumulation of intracellular (tau) neurofibrillary tangles are the hallmarks of this disease. We aim to investigate serum thyroid function tests in Alzheimer's disease, in addition to other dementias, and geriatric Turkish patients. We evaluated patients from Ankara, Dokuz Eylul, Cukurova University Hospitals. 357 female and male geriatric subjects were enrolled. All the cases were selected from three different geographical regions irrespective of sex and socioeconomic status. In this study, we evaluated the results of thyroid functions in Alzheimer disease patients as well as in other dementias and geriatric patients. In patients from Ankara, Central Anatolia region, no significant difference between groups regarding the routine control of biochemical parameters was observed. However, thyroid function results revealed that hypothyroidism in Alzheimer's disease patients from Mediterranean region, Adana and Aegean region, Izmir is a recurrent medical condition and is often an embedded side of the normal aging process. We concluded that currently, routine thyroid functions tests should be a part of all geriatric patients for screening presymptomatic Alzheimer's disease. There might be an interplay between reduced thyroid function and Alzheimer's disease that could be exploited for diagnostic purposes.
dc.description.indexedbyWOS
dc.description.issue2
dc.description.openaccessNO
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume32
dc.identifier.issn1302-1664
dc.identifier.quartileQ4
dc.identifier.urihttps://hdl.handle.net/20.500.14288/16120
dc.identifier.wos361529400006
dc.keywordsAlzheimer's disease
dc.keywordsThyrotropin (TSH) and free thyroxine (T4)
dc.keywordsFree triiodothyronine (T3)
dc.keywordsSubclinical hypothyroidism
dc.keywordsCognitive function
dc.keywordsHormone action
dc.keywordsKidney cortex
dc.keywordsRisk
dc.keywordsProtein
dc.keywordsBrain
dc.keywordsGlucose-6-phosphate-dehydrogenase
dc.keywordsInhibition
dc.keywordsRotterdam
dc.language.isoeng
dc.publisherJournal Neurological Sciences
dc.relation.ispartofJournal of Neurological Sciences / Türk Nöroloji Dergisi
dc.subjectNeurosciences
dc.titleA comparative study on thyroid function in alzheimer's disease: results from a Turkish multi-centre study
dc.title.alternativeAlzheimer hastalığında tiroid fonksiyonları üzerine karşılaştırmalı bir çalışma: Türkiye'den çok merkezli araştırma sonuçları
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorUlusu, Nuriye Nuray
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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