Publication:
Effect of continuous positive airway pressure on lipid profiles in obstructive sleep apnea: a meta-analysis

dc.contributor.coauthorChen, B.
dc.contributor.coauthorGuo, M.
dc.contributor.coauthorSalord, N.
dc.contributor.coauthorDrager, L.F.
dc.contributor.coauthorLorenzi Filho, G.
dc.contributor.coauthorTang, X.
dc.contributor.coauthorLi, Y.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorPeker, Yüksel
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T12:27:04Z
dc.date.issued2022
dc.description.abstractBackground: obstructive sleep apnea (OSA) is associated with dyslipidemia. However, the effects of continuous positive airway pressure (CPAP) treatment on lipid profiles are unclear. Methods: PubMed/Medline, Embase and Cochrane were searched up to July 2021. Randomized controlled trials (RCTs) of CPAP versus controls with ?4 weeks treatment and reported pre-and post-intervention lipid profiles were included. Weighted mean difference (WMD) was used to assess the effect size. Meta-regression was used to explore the potential moderators of post-CPAP treatment changes in lipid profiles. Results: a total of 14 RCTs with 1792 subjects were included. CPAP treatment was associated with a significant decrease in total cholesterol compared to controls (WMD = ?0.098 mmol/L, 95% CI = ?0.169 to ?0.027, p = 0.007, I2 = 0.0%). No significant changes in triglyceride, high-density lipoprotein nor low-density lipoprotein were observed after CPAP treatment (all p > 0.2). Furthermore, meta-regression models showed that age, gender, body mass index, daytime sleepiness, OSA severity, follow-up study duration, CPAP compliance nor patients with cardiometabolic disease did not moderate the effects of CPAP treatment on lipid profiles (all p > 0.05). Conclusions: CPAP treatment decreases total cholesterol at a small magnitude but has no effect on other markers of dyslipidemia in OSA patients. Future studies of CPAP therapy should target combined treatment strategies with lifestyle modifications and/or anti-hyperlipidemic medications in the primary as well as secondary cardiovascular prevention models.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipNational Natural Science Foundation of China (NSFC)
dc.description.sponsorshipGuangdong High-level University Development Program
dc.description.sponsorshipKey Disciplinary Project of Clinical Medicine
dc.description.sponsorshipGuangdong Province Science and Technology Special Fund project
dc.description.sponsorshipLi Ka Shing Foundation Cross-Disciplinary Research Grant
dc.description.versionPublisher version
dc.description.volume11
dc.identifier.doi10.3390/jcm11030596
dc.identifier.eissn2077-0383
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03440
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85123380276
dc.identifier.urihttps://doi.org/10.3390/jcm11030596
dc.identifier.wos759598600001
dc.keywordsContinuous positive airway pressure
dc.keywordsLipid profile
dc.keywordsObstructive sleep apnea
dc.keywordsTotal cholesterol
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.grantno81970087
dc.relation.grantno200115165870512
dc.relation.grantno2020LKSFG05B
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10235
dc.subjectGeneral and internal medicine
dc.titleEffect of continuous positive airway pressure on lipid profiles in obstructive sleep apnea: a meta-analysis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorPeker, Yüksel
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
10235.pdf
Size:
743.08 KB
Format:
Adobe Portable Document Format