Publication: Effect of continuous positive airway pressure on lipid profiles in obstructive sleep apnea: a meta-analysis
dc.contributor.coauthor | Chen, B. | |
dc.contributor.coauthor | Guo, M. | |
dc.contributor.coauthor | Salord, N. | |
dc.contributor.coauthor | Drager, L.F. | |
dc.contributor.coauthor | Lorenzi Filho, G. | |
dc.contributor.coauthor | Tang, X. | |
dc.contributor.coauthor | Li, Y. | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Peker, Yüksel | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T12:27:04Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Background: obstructive sleep apnea (OSA) is associated with dyslipidemia. However, the effects of continuous positive airway pressure (CPAP) treatment on lipid profiles are unclear. Methods: PubMed/Medline, Embase and Cochrane were searched up to July 2021. Randomized controlled trials (RCTs) of CPAP versus controls with ?4 weeks treatment and reported pre-and post-intervention lipid profiles were included. Weighted mean difference (WMD) was used to assess the effect size. Meta-regression was used to explore the potential moderators of post-CPAP treatment changes in lipid profiles. Results: a total of 14 RCTs with 1792 subjects were included. CPAP treatment was associated with a significant decrease in total cholesterol compared to controls (WMD = ?0.098 mmol/L, 95% CI = ?0.169 to ?0.027, p = 0.007, I2 = 0.0%). No significant changes in triglyceride, high-density lipoprotein nor low-density lipoprotein were observed after CPAP treatment (all p > 0.2). Furthermore, meta-regression models showed that age, gender, body mass index, daytime sleepiness, OSA severity, follow-up study duration, CPAP compliance nor patients with cardiometabolic disease did not moderate the effects of CPAP treatment on lipid profiles (all p > 0.05). Conclusions: CPAP treatment decreases total cholesterol at a small magnitude but has no effect on other markers of dyslipidemia in OSA patients. Future studies of CPAP therapy should target combined treatment strategies with lifestyle modifications and/or anti-hyperlipidemic medications in the primary as well as secondary cardiovascular prevention models. | |
dc.description.fulltext | YES | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 3 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | National Natural Science Foundation of China (NSFC) | |
dc.description.sponsorship | Guangdong High-level University Development Program | |
dc.description.sponsorship | Key Disciplinary Project of Clinical Medicine | |
dc.description.sponsorship | Guangdong Province Science and Technology Special Fund project | |
dc.description.sponsorship | Li Ka Shing Foundation Cross-Disciplinary Research Grant | |
dc.description.version | Publisher version | |
dc.description.volume | 11 | |
dc.identifier.doi | 10.3390/jcm11030596 | |
dc.identifier.eissn | 2077-0383 | |
dc.identifier.embargo | NO | |
dc.identifier.filenameinventoryno | IR03440 | |
dc.identifier.quartile | Q2 | |
dc.identifier.scopus | 2-s2.0-85123380276 | |
dc.identifier.uri | https://doi.org/10.3390/jcm11030596 | |
dc.identifier.wos | 759598600001 | |
dc.keywords | Continuous positive airway pressure | |
dc.keywords | Lipid profile | |
dc.keywords | Obstructive sleep apnea | |
dc.keywords | Total cholesterol | |
dc.language.iso | eng | |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | |
dc.relation.grantno | 81970087 | |
dc.relation.grantno | 200115165870512 | |
dc.relation.grantno | 2020LKSFG05B | |
dc.relation.ispartof | Journal of Clinical Medicine | |
dc.relation.uri | http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10235 | |
dc.subject | General and internal medicine | |
dc.title | Effect of continuous positive airway pressure on lipid profiles in obstructive sleep apnea: a meta-analysis | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Peker, Yüksel | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
relation.isOrgUnitOfPublication | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isOrgUnitOfPublication.latestForDiscovery | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isParentOrgUnitOfPublication | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e | |
relation.isParentOrgUnitOfPublication.latestForDiscovery | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e |
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