Publication: Hepatic cysts reappraisal of the classification, terminology, differential diagnosis, and clinicopathologic characteristics in 258 cases
dc.contributor.coauthor | Quigley, Brian | |
dc.contributor.coauthor | Choi, Hegyong | |
dc.contributor.coauthor | Basturk, Olca | |
dc.contributor.coauthor | Akkas, Gizem | |
dc.contributor.coauthor | Pehlivanoglu, Burcin | |
dc.contributor.coauthor | Memis, Bahar | |
dc.contributor.coauthor | Jang, Kee-Taek | |
dc.contributor.coauthor | Erkan, Mert | |
dc.contributor.coauthor | Erkan, Burcu | |
dc.contributor.coauthor | Balci, Serdar | |
dc.contributor.coauthor | Bagci, Pelin | |
dc.contributor.coauthor | Farris, Alton B. | |
dc.contributor.coauthor | Kooby, David A. | |
dc.contributor.coauthor | Martin, Diego | |
dc.contributor.coauthor | Kalb, Bobby | |
dc.contributor.coauthor | Maithel, Shishir K. | |
dc.contributor.coauthor | Sarmiento, Juan | |
dc.contributor.coauthor | Reid, Michelle D. | |
dc.contributor.department | KUTTAM (Koç University Research Center for Translational Medicine) | |
dc.contributor.department | KUH (Koç University Hospital) | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Adsay, Nazmi Volkan | |
dc.contributor.kuauthor | Armutlu, Ayşe | |
dc.contributor.kuauthor | Erkan, Burcu | |
dc.contributor.kuauthor | Saka, Burcu | |
dc.contributor.schoolcollegeinstitute | KUH (KOÇ UNIVERSITY HOSPITAL) | |
dc.contributor.schoolcollegeinstitute | Research Center | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T23:06:49Z | |
dc.date.issued | 2022 | |
dc.description.abstract | The literature on liver cysts is highly conflicting, mostly owing to definitional variations. Two hundred and fifty-eight >= 1 cm cysts evaluated pathologically using updated criteria were classifiable as: I. Ductal plate malformation related (63%); that is, cystic bile duct hamartoma or not otherwise specified-type benign biliary cyst (35 with polycystic liver disease). These were female predominant (F/M=2.4), large (10 cm), often multifocal with degenerative/inflammatory changes and frequently misclassified as "hepatobiliary cystadenoma." II. Neoplastic (13%); 27 (10.5%) had ovarian-type stroma (OTS) and qualified as mucinous cystic neoplasm (MCN) per World Health Organization (WHO). These were female, solitary, mean age 52, mean size 11 cm, and 2 were associated with carcinoma (1 in situ and 1 microinvasive). There were 3 intraductal papillary neoplasms, 1 intraductal oncocytic papillary neoplasm, 1 cystic cholangiocarcinoma, and 2 cystic metastasis. III. Infectious/inflammatory (12%). These included 23 hydatid cysts (including 2 Echinococcus alveolaris both misdiagnosed preoperatively as cancer), nonspecific inflammatory cysts (abscesses, inflammatory cysts: 3.4%). IV. Congenital (7%). Mostly small (<3 cm); choledochal cyst (5%), foregut cyst (2%). V. Miscellaneous (4%). In conclusion, hepatic cysts occur predominantly in women (3/1), are mostly (90%) non-neoplastic, and seldom (<2%) malignant. Cystic bile duct hamartomas and their relative not otherwise specified-type benign biliary cysts are frequently multifocal and often misdiagnosed as "cystadenoma/carcinoma." Defined by OTS, MCNs (the true "hepatobiliary cystadenoma/carcinoma") are solitary, constitute only 10.5% of hepatic cysts, and have a significantly different profile than the impression in the literature in that essentially all are perimenopausal females, and rarely associated with carcinoma (7%). Since MCNs can only be diagnosed by demonstration of OTS through complete microscopic examination, it is advisable to avoid the term "cystadenoma/cystadenocarcinoma" solely based on radiologic examination, and the following simplified terminology would be preferable in preoperative evaluation to avoid conflicts with the final pathologic diagnosis: (1) noncomplex (favor benign), (2) complex (in 3 subsets, as favor benign, cannot rule out malignancy, or favor malignancy), (3) malignant features. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 9 | |
dc.description.openaccess | NO | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 46 | |
dc.identifier.doi | 10.1097/PAS.0000000000001930 | |
dc.identifier.eissn | 1532-0979 | |
dc.identifier.issn | 0147-5185 | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85136496998 | |
dc.identifier.uri | https://doi.org/10.1097/PAS.0000000000001930 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/9043 | |
dc.identifier.wos | 840881200005 | |
dc.keywords | Hepatic cysts | |
dc.keywords | Liver cysts | |
dc.keywords | Biliary cystadenoma | |
dc.keywords | Biliary cystadenocarcinoma | |
dc.keywords | Neoplasia | |
dc.language.iso | eng | |
dc.publisher | Lippincott Williams and Wilkins (LWW) | |
dc.relation.ispartof | American Journal of Surgical Pathology | |
dc.subject | Pathology | |
dc.subject | Surgery | |
dc.title | Hepatic cysts reappraisal of the classification, terminology, differential diagnosis, and clinicopathologic characteristics in 258 cases | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Armutlu, Ayşe | |
local.contributor.kuauthor | Erkan, Burcu | |
local.contributor.kuauthor | Saka, Burcu | |
local.contributor.kuauthor | Adsay, Nazmi Volkan | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit1 | Research Center | |
local.publication.orgunit1 | KUH (KOÇ UNIVERSITY HOSPITAL) | |
local.publication.orgunit2 | KUTTAM (Koç University Research Center for Translational Medicine) | |
local.publication.orgunit2 | KUH (Koç University Hospital) | |
local.publication.orgunit2 | School of Medicine | |
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