Publication:
Antimicrobial activities of phosphonium containing polynorbornenes

dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorYalçın, Özlem
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T12:29:46Z
dc.date.issued2016
dc.description.abstractIn this study, amphiphilic polyoxanorbornene with different alkyl and aromatic phosphonium side chains was synthesized. The biological activities of these polymers were determined by the minimal inhibitory concentration (MIC) against E. coli, S. aureus, M. tuberculosis and the yeast C. albicans, and cytotoxicity studies on red blood cells were performed. A series of polymers with different alkyl and aromatic substituents (methyl, ethyl, tripropyl, tert-butyl, phenyl, and tris 4-methoxyphenyl) and two types different molecular weight, 3000 g mol(-1) and 10 000 g mol(-1), were prepared. It was observed that the biological activity of the polymers with aromatic group substituents had an MIC of 16, 8, 64 and 128 mu g mL(-1) against E. coli, S. aureus, M. tuberculosis and C. albicans, respectively, while those with nonaromatic carbons had a higher MIC compared to those with aromatic carbons. The aromaticity of the repeat unit had impressive effects on hemolytic activities as well. Zeta potential measurements of E. coli incubated with active and inactive polymer concentration revealed a relationship between the MIC and membrane surface charge density. Polymers bearing aromatic groups killed the bacteria with widespread damage after the polymers, holding the threshold concentration, were added to the bacteria.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue89
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TÜBİTAK)
dc.description.sponsorshipCOST Action CM1302 SIPs
dc.description.versionPublisher version
dc.description.volume6
dc.identifier.doi10.1039/c6ra15545f
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR00848
dc.identifier.issn2046-2069
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-84987887604
dc.identifier.urihttps://hdl.handle.net/20.500.14288/1871
dc.identifier.wos384322700057
dc.keywordsAmphiphilic polymethacrylate derivatives
dc.keywordsOpening metathesis polymerization
dc.keywordsHost-defense peptides
dc.keywordsMycobacterium-tuberculosis
dc.keywordsInfectious-diseases
dc.keywordsEscherichia-coli
dc.keywordsBlock-copolymers
dc.keywordsSynthetic mimics
dc.keywordsCell-wall
dc.keywordsBad bugs
dc.language.isoeng
dc.publisherRoyal Society of Chemistry (RSC)
dc.relation.grantno113S355
dc.relation.ispartofRSC Advances
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/844
dc.subjectMultidisciplinary chemistry
dc.titleAntimicrobial activities of phosphonium containing polynorbornenes
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorYalçın, Özlem
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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