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A potential non-invasive glioblastoma treatment: nose-to-brain delivery of farnesylthiosalicylic acid incorporated hybrid nanoparticles

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GRADUATE SCHOOL OF HEALTH SCIENCES
Upper Org Unit
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SCHOOL OF MEDICINE
Upper Org Unit

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Lüle, Sevda
Pehlivan, Sibel Bozdağ
Ɩztürk, Naile
Kara, Aslı
Kaffashi, Abbas
Vural, Imran
Işıkay, Ilkay
Yavuz, BurƧin
Oguz, Kader Karlı
Söylemezoğlu, Figen

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New drug delivery systems are highly needed in research and clinical area to effectively treat gliomas by reaching a high antineoplastic drug concentration at the target site without damaging healthy tissues. Intranasal (IN) administration, an alternative route for non-invasive drug delivery to the brain, bypasses the blood-brainbarrier (BBB) and eliminates systemic side effects. This study evaluated the antitumor efficacy of farnesylthiosalicylic acid (FTA) loaded (lipid-cationic) lipid-PEG-PLGA hybrid nanoparticles (HNPs) after IN application in rats. FTA loaded HNPs were prepared, characterized and evaluated for cytotoxicity. Rat glioma 2 (RG2) cells were implanted unilaterally into the right striatum of female Wistar rats. 10 days later, glioma bearing rats received either no treatment, or 5 repeated doses of 500 mu M freshly prepared FTA loaded HNPs via IN or intravenous (IV) application. Pre-treatment and post-treatment tumor sizes were determined with MRI. After a treatment period of 5 days, IN applied FTA loaded HNPs achieved a significant decrease of 55.7% in tumor area, equal to IV applied FTA loaded HNPs. Herewith, we showed the potential utility of IN application of FTA loaded HNPs as a non-invasive approach in glioblastoma treatment.

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Elsevier

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Chemistry, Pharmacology, Pharmacy

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Journal of Controlled Release

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DOI

10.1016/j.jconrel.2017.06.032

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