Publication:
The Turkish experience of COVID-19 infection in people with NMOSD and MOGAD: a milder course?

dc.contributor.coauthorŞen, S.
dc.contributor.coauthorTuncer, A.
dc.contributor.coauthorÖzakbaş, S.
dc.contributor.coauthorUzunköprü, C.
dc.contributor.coauthorBaba, C.
dc.contributor.coauthorDemir, S.
dc.contributor.coauthorBeckmann, Y.
dc.contributor.coauthorGümüş, H.
dc.contributor.coauthorArslan, G.
dc.contributor.coauthorKılıç, A.K.
dc.contributor.coauthorYüceyar, N.
dc.contributor.coauthorTuran, O.F.
dc.contributor.coauthorTütüncü, M.
dc.contributor.coauthorTerzi, M.
dc.contributor.coauthorAcar, P.
dc.contributor.coauthorBünül, S.D.
dc.contributor.coauthorBalcı, B.P.
dc.contributor.coauthorBir, L.S.
dc.contributor.coauthorKöseoğlu, M.
dc.contributor.coauthorMungan, S.
dc.contributor.coauthorGündüz, T.
dc.contributor.coauthorDoğan, I.G.
dc.contributor.coauthorKotan, D.
dc.contributor.coauthorUygunoğlu, U.
dc.contributor.coauthorEkmekçi, O.
dc.contributor.coauthorDemirkiran, M.
dc.contributor.coauthorKamışlı O.
dc.contributor.coauthorKabay, S.C.
dc.contributor.coauthorTamam, Y.
dc.contributor.coauthorÖmerhoca, S.
dc.contributor.coauthorSevim, S.
dc.contributor.coauthorGüler, S.
dc.contributor.coauthorKürtüncü, M.
dc.contributor.coauthorEfendi, H.
dc.contributor.coauthorKarabudak, R.
dc.contributor.coauthorŞiva A.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAltıntaş, Ayşe
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T13:23:29Z
dc.date.issued2021
dc.description.abstractBackground: COVID-19 is a multisystemic infection with variables consequences depending on individual and comorbid conditions. The course and outcomes of COVID-19 during neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) are not clearly known. Objective methods: the aim of this study was to examine the features and outcomes of COVID-19 infection in NMOSD and MOGAD patients. The patients' demographic and clinical factors, disease modifying treatment (DMT) used and disease information of COVID-19 infection were recorded. Conditions leading to hospitalization and severe exposure to COVID-19 infection were also analyzed. Results: the study included 63 patients from 25 centers. Thirty-two patients (50.8%) belong to AQP-4 seropositive group, 13 (20.6%) and 18 (28.6%) were in MOG-positive and double-seronegative groups, respectively. Risk factors for severe COVID-19 infection and hospitalization were advanced age, high disability level and the presence of comorbid disease. Disease severity was found to be high in double-seronegative NMOSD and low in MOGAD patients. No statistically significant effect of DMTs on disease severity and hospitalization was found. Conclusion: in NMOSD and MOGAD patients, advanced age, high disability and presence of comorbid disease pose risks for severe COVID-19 infection. There was no direct significant effect of DMTs for COVID-19 infection.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume58
dc.identifier.doi10.1016/j.msard.2021.103399
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03468
dc.identifier.issn2211-0348
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85122957692
dc.identifier.urihttps://hdl.handle.net/20.500.14288/3372
dc.identifier.wos793561600010
dc.keywordsCoronavirus
dc.keywordsDisease modifying treatment
dc.keywordsMyelin oligodendrocyte glycoprotein antibody-associated disorders
dc.keywordsNeuromyelitis optica spectrum disorders
dc.keywordsSARS-CoV-2
dc.language.isoeng
dc.publisherElsevier
dc.relation.grantnoNA
dc.relation.ispartofMultiple Sclerosis and Related Disorders
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10262
dc.subjectMedicine, general and internal
dc.titleThe Turkish experience of COVID-19 infection in people with NMOSD and MOGAD: a milder course?
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAltıntaş, Ayşe
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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