Publication:
Prognostic value of pulmonary artery pulsatility index in chronic heart failure patients with reduced ejection fraction

dc.contributor.coauthorYıldız, Ömer
dc.contributor.kuauthorBaydar, Onur
dc.contributor.kuprofileDoctor
dc.contributor.unitKoç University Hospital
dc.contributor.yokidN/A
dc.date.accessioned2024-11-09T23:00:38Z
dc.date.issued2022
dc.description.abstractBackground The co-existence of right ventricular dysfunction (RVD) in heart failure patient with reduced ejection fraction (HFrEF) is an independent maker of poor prognosis. A novel right ventricular hemodynamic composite measure is the pulmonary artery pulsatility index (PAPi), which is the pulmonary artery pressure gradient ratio. It is a strong predictor of RVD in patients with acute inferior myocardial infarction and patients undergoing left ventricular assist device (LVAD) implantation. However, little is known about its prognostic value in patients with HFrEF. Methods Between September 2010 and July 2013, 172 patients with HFrEF admitted to the tertiary hospital were included in this analysis. We carried out a cardiac catheterisation for each patient, at baseline. Subsequently, we evaluated both PAPi and the other hemodynamic parameters with longitudinal follow-up of adverse outcomes such as cardiac mortality, LVAD, and heart transplantation (HTx). Results During a median follow-up period of 52 months we observed 50 cardiac deaths, 12 LVAD implantations and 10 HTx. A threshold for PAPi value of 2.82 was ascertained (Area: 0.76, p < 0.001, CI: 0.67-0.85, sensitivity 67%, specificity 69%). After dividing the study population into two groups, PAPi <= 2.82 and PAPi >2.82, no significant difference was demonstrated with respect to the aetiology of heart failure (ischaemic HFrEF p = 0.29 and non-ischaemic HFrEF p = 0.29). In Cox regression survival analysis, PAPi was an independent predictor of cardiac death (hazard ratio 0.73 [95% confidence interval 0.53-0.99], p = 0.045). Conclusion In patients with HFrEF, a low PAPi value (<2.82) was associated with increased cardiac mortality risk.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.1080/00015385.2021.1950369
dc.identifier.eissn1784-973X
dc.identifier.issn0001-5385
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85127918944
dc.identifier.urihttp://dx.doi.org/10.1080/00015385.2021.1950369
dc.identifier.urihttps://hdl.handle.net/20.500.14288/8088
dc.identifier.wos750937600001
dc.keywordsPulmonary artery pulsatility index
dc.keywordsRight ventricular failure
dc.keywordsHeart failure
dc.keywordsMortality
dc.keywordsPrognosis right-Ventricular dysfunction guidelines
dc.keywordsSociety
dc.languageEnglish
dc.publisherTaylor & Francis Ltd
dc.sourceActa Cardiologica
dc.subjectCardiac & cardiovascular systems
dc.titlePrognostic value of pulmonary artery pulsatility index in chronic heart failure patients with reduced ejection fraction
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authoridN/A
local.contributor.kuauthorBaydar, Onur

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