Publication:
Patients with gynecological malignancies are similar to other IVF patients without cancer for clinical and molecular reproductive parameters and DNA damage response pattern

dc.contributor.coauthorTuran, Volkan
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorEsmaeilian, Yashar
dc.contributor.kuauthorİltümür, Ece
dc.contributor.kuauthorİncir, Said
dc.contributor.kuauthorÖktem, Özgür
dc.contributor.kuauthorTaşkıran, Çağatay
dc.contributor.kuauthorUğurlu Çimen, Deniz
dc.contributor.kuauthorUrman, Cumhur Bülent
dc.contributor.kuauthorVatansever, Doğan
dc.contributor.kuauthorYakın, Kayhan
dc.contributor.kuauthorYusufoğlu, Sevgi
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:39:47Z
dc.date.issued2024
dc.description.abstractThis study intended to investigate if gynecological cancers compromise ovarian function and reduce the success of assisted reproduction techniques (ART). No clinical and molecular data together is available on this issue for gynecological or other organ cancers. Steroidogenic pathways and DNA damage response characteristics of the granulosa cells retrieved from the 39 gynecological cancer patients were analyzed together with their clinical ART characteristics in comparison to 31 control ART patients. Patients with gynecological malignancies were similar to the control IVF patients for the number of mature oocytes retrieved, fertilization rates and embryo development competency. Molecular analyses of the granulosa cells retrieved from these cancer patients did not detect any perturbations in gonadotropin receptor expression and response, sex steroid production, cholesterol utilization/storage and, DNA damage response pattern in comparison to control IVF patients without cancer. This study provides the first reassuring clinical and molecular combined data set that the presence of gynecological malignancy does not appear to have any detrimental effect on clinical IVF cycle characteristics and ovarian functioning at molecular level.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessGold Open Access
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThe authors gratefully acknowledge the use of the services and facilities of the Koc University Research Center for Translational Medicine (KUTTAM), funded by the Presidency of Turkey, Presidency of Strategy and Budget.
dc.description.volume14
dc.identifier.doi10.1038/s41598-024-64403-y
dc.identifier.issn2045-2322
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85195806128
dc.identifier.urihttps://doi.org/10.1038/s41598-024-64403-y
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23092
dc.identifier.wos1249273400006
dc.keywordsOvarian stimulation
dc.keywordsFertility preservation
dc.keywordsReserve
dc.keywordsImpact
dc.keywordsExpression
dc.keywordsOutcomes
dc.keywordsStage
dc.language.isoeng
dc.publisherNature Portfolio
dc.relation.ispartofScientific Reports
dc.subjectMalignant neoplasm
dc.subjectFemale fertility
dc.subjectChemotherapy
dc.titlePatients with gynecological malignancies are similar to other IVF patients without cancer for clinical and molecular reproductive parameters and DNA damage response pattern
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorEsmaeilian, Yashar
local.contributor.kuauthorYusufoğlu, Sevgi
local.contributor.kuauthorİltümür, Ece
local.contributor.kuauthorUğurlu Çimen, Deniz
local.contributor.kuauthorVatansever, Doğan
local.contributor.kuauthorTaşkıran, Çağatay
local.contributor.kuauthorYakın, Kayhan
local.contributor.kuauthorİncir, Said
local.contributor.kuauthorUrman, Cumhur Bülent
local.contributor.kuauthorÖktem, Özgür
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1Research Center
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
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