Publication: LoC sensor array platform for real-time coagulation measurements
Program
KU Authors
Co-Authors
Yaralıoğlu, Göksenin G.
Publication Date
Language
Embargo Status
Journal Title
Journal ISSN
Volume Title
Alternative Title
Abstract
This paper reports a MEMS-based sensor array enabling multiple clot-time tests in one disposable microfluidic cartridge using plasma. The versatile LoC (Lab-on-Chip) platform technology is demonstrated here for real-time coagulation tests (activated Partial Thrompoblastin Time (aPTT) and Prothrombin Time (PT)). The system has a reader unit and a disposable cartridge. The reader has no electrical connections to the cartridge, which consists of multiple microfluidic channels and MEMS microcantilevers placed in each channel. Microcantilevers are made of electro-plated nickel and actuated remotely using an external electro-coil. The read-out is also conducted remotely by a laser and the phase of the MEMS oscillator is monitored real-time. The system is capable of monitoring coagulation time with a precision estimated at 0.1sec.
Source
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Subject
Engineering, Electrical electronic engineering
Citation
Has Part
Source
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Book Series Title
Edition
DOI
10.1109/MEMSYS.2014.6765643