Publication:
Hypertension as an autoimmune and inflammatory disease

dc.contributor.coauthorSolak, Yalcin
dc.contributor.coauthorAfsar, Baris
dc.contributor.coauthorVaziri, Nosratola D.
dc.contributor.coauthorCovic, Adrian
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAslan, Gamze
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuauthorYalçın, Can Ege
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:25:21Z
dc.date.issued2016
dc.description.abstractHypertension that is considered idiopathic is called essential hypertension and accordingly has no clear culprit for its cause. However, basic research and clinical studies in recent years have expanded our understanding of the mechanisms underlying the development of essential hypertension. of these, increased oxidative stress, both in the kidney and arterial wall, closely coupled with inflammatory infiltration now appear to have a prominent role. Discovery of regulatory and interleukin-17-producing T cells has enabled us to better understand the mechanism by which inflammation and autoimmunity, or autoinflammation, lead to the development of hypertension. Despite achieving considerable progress, the intricate interactions between oxidative stress, the immune system and the development of hypertension remain to be fully elucidated. In this review, we summarize recent developments in the pathophysiology of hypertension with a focus on the oxidant stress-autoimmunity-inflammation interaction.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue8
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume39
dc.identifier.doi10.1038/hr.2016.35
dc.identifier.eissn1348-4214
dc.identifier.issn0916-9636
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-84982789672
dc.identifier.urihttps://doi.org/10.1038/hr.2016.35
dc.identifier.urihttps://hdl.handle.net/20.500.14288/11365
dc.identifier.wos380812300002
dc.keywordsAutoimmune disease
dc.keywordsInflammation
dc.language.isoeng
dc.publisherNature Publishing Group (NPG)
dc.relation.ispartofHypertension Research
dc.subjectPeripheral vascular disease
dc.titleHypertension as an autoimmune and inflammatory disease
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorAslan, Gamze
local.contributor.kuauthorYalçın, Can Ege
local.contributor.kuauthorKanbay, Mehmet
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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