Publication:
Pretreatment masseter muscle volume predicts survival in locally advanced nasopharyngeal carcinoma patients treated with concurrent chemoradiotherapy

dc.contributor.coauthorPehlivan, Umur Anil
dc.contributor.coauthorSomay, Efsun
dc.contributor.coauthorYilmaz, Busra
dc.contributor.coauthorBesen, Ali Ayberk
dc.contributor.coauthorMertsoylu, Huseyin
dc.contributor.coauthorTopkan, Erkan
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSelek, Uğur
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:40:26Z
dc.date.issued2023
dc.description.abstractBackground and Purpose: Muscle loss is a significant indicator of cancer cachexia and is associated with a poor prognosis in cancer patients. Given the absence of comparable studies, the current retrospective study sought to examine the correlation between the total masseter muscle volume (TMMV) before treatment and the survival outcomes in locally advanced nasopharyngeal cancer (LA-NPC) patients who received definitive concurrent chemoradiotherapy (CCRT). Methods: A three-dimensional segmentation model was used to determine the TMMV for each patient by analyzing pre-CCRT magnetic resonance imaging. The optimal TMMV cutoff values were searched using receiver operating characteristic (ROC) curve analyses. The primary and secondary endpoints were the relationship between the pre-CCRT TMMV measures and overall survival (OS) and progression-free survival (PFS), respectively. Results: Ninety-seven patients were included in this study. ROC curve analyses revealed 38.0 cc as the optimal TMMV cutoff: <= 38.00 cc (n = 42) and >38.0 cc (n = 55). Comparisons between the two groups showed that the TMMV>38.0 cc group had significantly longer PFS [Not reached (NR) vs. 28; p < 0.01] and OS (NR vs. 71; p < 0.01) times, respectively. The results of the multivariate analysis demonstrated that the T-stage, N-stage, number of concurrent chemotherapy cycles, and TMMV were independent associates of PFS (p < 0.05 for each) and OS (p < 0.05 for each) outcomes, respectively. Conclusion: The findings of the current retrospective research suggest that pretreatment TMMV is a promising indicator for predicting survival outcomes in LA-NPC patients receiving definitive CCRT.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue21
dc.description.openaccessgold, Green Published
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThe APC was funded by Baskent University Adana Dr. Turgut Noyan Application and Research Center.
dc.description.volume12
dc.identifier.doi10.3390/jcm12216863
dc.identifier.eissn2077-0383
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85176556621
dc.identifier.urihttps://doi.org/10.3390/jcm12216863
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23323
dc.identifier.wos1103246100001
dc.keywordsMuscle loss
dc.keywordsMasseter muscle
dc.keywordsLocally advanced nasopharyngeal cancer
dc.keywordsChemoradiotherapy
dc.keywordsSurvival
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.grantnoBaskent University Adana Dr. Turgut Noyan Application and Research Center
dc.relation.ispartofJournal of Clinical Medicine
dc.subjectMedicine
dc.subjectGeneral
dc.subjectInternal
dc.titlePretreatment masseter muscle volume predicts survival in locally advanced nasopharyngeal carcinoma patients treated with concurrent chemoradiotherapy
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorSelek, Uğur
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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