Publication:
Prognostic impact and clinical features of spread through air spaces in operated lung cancer: real-world analysis

dc.contributor.coauthorYildirim, Sedat
dc.contributor.coauthorYuksel Yasar, Zeynep
dc.contributor.coauthorKaya, Tugba
dc.contributor.coauthorAkdag, Goncagul
dc.contributor.coauthorKinikoglu, Oguzcan
dc.contributor.coauthorGecmen, Gonca Gul
dc.contributor.coauthorYasar, Alper
dc.contributor.coauthorIsik, Deniz
dc.contributor.coauthorSurmeli, Heves
dc.contributor.coauthorBasoglu, Tugba
dc.contributor.coauthorSever, Ozlem Nuray
dc.contributor.coauthorYildirim, Mahmut Emre
dc.contributor.coauthorOdabas, Hatice
dc.contributor.coauthorTuran, Nedim
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.kuauthorAlan, Özkan
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.date.accessioned2024-12-29T09:38:53Z
dc.date.issued2024
dc.description.abstractBackground and Objectives: Lung cancer is the leading cause of cancer-related deaths. Spread through air spaces (STAS) is an adverse prognostic factor that has become increasingly known in recent years. This study aims to investigate the impact of STAS presence on overall survival (OS) and disease-free survival (DFS) in patients with surgically resected stage IA-IIIA lung cancer and to identify clinicopathological features associated with STAS. Materials and Methods: This research involved 311 lung cancer surgery patients. The relationship between the presence of STAS in the patients’ surgical pathology and OS and DFS values was examined. Clinicopathological features associated with the presence of STAS were determined. Results: There were 103 (33%) STAS-positive patients. Adenocarcinoma histological subtype, perineural invasion (PNI), and lymphovascular invasion (LVI) were significantly correlated with being STAS positive. STAS significantly predicted DFS and OS. One-year and five-year DFS rates were significantly lower in the STAS-positive group compared to the STAS-negative group (65% vs. 88%, 29% vs. 62%, respectively, p ≤ 0.001). Similarly, one-year and five-year OS rates were significantly lower in the STAS-positive group compared to the STAS-negative group (92% vs. 94%, 54% vs. 88%, respectively, p ≤ 0.001). In multivariate analysis, STAS was found to be an independent prognostic factor for both DFS and OS (HR: 3.2 (95%CI: 2.1–4.8) and 3.1 (95%CI: 1.7–5.5), p < 0.001 and <0.001, respectively). Conclusions: In our study, STAS was found to be an independent prognostic biomarker in operated stage IA-IIIA lung cancer patients. It may be a beneficial pathological biomarker in predicting the survival of patients and managing their treatments.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue8
dc.description.openaccessAll Open Access
dc.description.openaccessGold Open Access
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume60
dc.identifier.doi10.3390/medicina60081374
dc.identifier.eissn1648-9144
dc.identifier.issn1010-660X
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85202624020
dc.identifier.urihttps://doi.org/10.3390/medicina60081374
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22837
dc.identifier.wos1307360100001
dc.keywordsDisease-free survival
dc.keywordsNon-small-cell lung cancer
dc.keywordsOverall survival
dc.keywordsPrognostic factor
dc.keywordsTumor spread through air spaces
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofMedicina (Lithuania)
dc.subjectMedicine
dc.subjectGeneral
dc.subjectInternal
dc.titlePrognostic impact and clinical features of spread through air spaces in operated lung cancer: real-world analysis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAlan, Özkan
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
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relation.isParentOrgUnitOfPublication055775c9-9efe-43ec-814f-f6d771fa6dee
relation.isParentOrgUnitOfPublication.latestForDiscovery055775c9-9efe-43ec-814f-f6d771fa6dee

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