Publication:
Assessment of disease activity and quality of life in patients with recurrent bradykinin-mediated versus mast cell-mediated angioedema

dc.contributor.coauthorCan, Pelin Kuteyla
dc.contributor.coauthorDeğirmentepe, Ece Nur
dc.contributor.coauthorEtikan, Pırıl
dc.contributor.coauthorKızıltaç, Kübra
dc.contributor.coauthorGelincik, Aslı
dc.contributor.coauthorDemir, Semra
dc.contributor.coauthorBüyüköztürk, Suna
dc.contributor.coauthorHasal, Eda
dc.contributor.coauthorBaşkan, Emel Bülbül
dc.contributor.coauthorAydin, Ömür
dc.contributor.coauthorMaurer, Marcus
dc.contributor.coauthorWeller, Karsten
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKocatürk Göncü, Özgür Emek
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T13:10:34Z
dc.date.issued2021
dc.description.abstractObjective: recurrent Angioedema (RAE) is characterized by sudden swelling of mucosal surfaces or deep dermis and is either mast cell-(MMAE) or bradykinin-mediated (BMAE). How patients with BMAE and MMAE differ in terms of disease activity and impact remains largely unknown. Here, we determined validity, reliability, and sensitivity to change of Turkish versions of angioedema activity score (AAS) and quality of life questionnaire (AE-QoL) and used both instruments to investigate and compare patients with BMAE and MMAE. Methods: Turkish versions of AAS28 and AE-QoL were applied to 94 patients with RAE (18–72 years). Patients’ global self-assessment of QoL (PGA-QoL), disease activity (PGA-DA-VRS, PatGA-DA-VAS), and 12-Item-Short Form Survey were used at week 4 (visit 2), and week 8 (visit 3). Demographic characteristics, clinical features, and AAS28 and AE-QoL values were compared between 31 patients with BMAE and 63 patients with MMAE. Results: Turkish AAS28 and AE-QoL showed excellent internal consistency, high reproducibility and known-groups validity. Compared to patients with MMAE, BMAE patients were younger (34.6 ± 10.7 vs. 40.7 ± 13.3 years), had longer disease duration (236 ± 178 vs. 51 ± 78 months), high prevalence of family history (63% vs 14%), longer duration of attacks (65 ± 20 vs. 40 ± 25 h), and they were more commonly affected by upper airway angioedema (70% vs 23%). Disease activity (AAS28) was lower (29.3 ± 24.6 vs 55.2 ± 52.9), but AE-QoL was higher (44.2 ± 16.1 vs 34.5 ± 22.5) in BMAE patients as compared to MMAE patients. Conclusions: patients with BMAE and MMAE have distinct disease characteristics. Recurrent bradykinin-mediated angioedema impacts quality of life more than mast cell-mediated angioedema. The discriminating characteristics of patients with BMAE and MMAE may help to improve the diagnosis and management of patients with RAE.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue7
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume14
dc.identifier.doi10.1016/j.waojou.2021.100554
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR02966
dc.identifier.issn1939-4551
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85107928494
dc.identifier.urihttps://hdl.handle.net/20.500.14288/2818
dc.identifier.wos682988700010
dc.keywordsAngioedema
dc.keywordsAngioedema activity score
dc.keywordsAngioedema quality of life questionnaire
dc.keywordsBradykinin mediated angioedema
dc.keywordsMast cell mediated angioedema
dc.language.isoeng
dc.publisherElsevier
dc.relation.grantnoNA
dc.relation.ispartofWorld Allergy Organization Journal
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9614
dc.subjectAllergy
dc.subjectImmunology
dc.titleAssessment of disease activity and quality of life in patients with recurrent bradykinin-mediated versus mast cell-mediated angioedema
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKocatürk Göncü, Özgür Emek
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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