First case of severe late ovarian hyperstimulation syndrome in a patient who was treated with in-vitro maturation of human oocytes and planed short gonadotropin stimulation

Abstract

In-vitro maturation is a technique used to perform assisted reproduction in women with high ovarian reserve, who are at risk for ovarian stimulation. With this technique occasionally 3-4 days of gonadotropins are planned to enlarge the follicles and aid in oocyte collection. Human choreinonic gonadotropin is also given to ease the collection. These few days of ovarian stimulation were felt to be insufficient to cause severe ovarian hyperstimlation syndrome. However, the case of a 32 year old women with polycystic ovary syndrome who underwent planned ovarian stimulation with four days of gonadotropins for a stimulated IVM cycle, and who developed severe ovarian hyperstimulation syndrome is presented. This is the first case of ovarian hyperstimulation syndrome in an IVM cycle. Clearly, only unstimulated IVM can be used to completely avoid ovarian hyperstimulation syndrome.