Publication:
Optimized hybrid arc for improved sparing of organs at risk: balanced combination of IMRT and VMAT in prostate cancer

dc.contributor.coauthorAyhan Bingölbalı
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSağlam, Yücel
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.date.accessioned2024-12-29T09:37:18Z
dc.date.issued2023
dc.description.abstractObjective: In order to seek a lower toxicity risk prediction in patients with prostate cancer, we have evaluated whether prescribing a potential hybrid radiotherapy of intensity-modulated radiotherapy (IMRT) & volumetric modulated arc therapy (VMAT) optimization might increase sparing of organs at risk (OAR) and target dose conformity. Methods: The cohort for this dosimetric planning study included ten consecutive prostate cancer patients previously treated with double arc VMAT to 78 Gy. New optimized hybrid arc plans for a combination of IMRT (8 step-and-shoot fix fields: 225°, 260°, 295°, 330°, 30°, 65°, 90°, 135°) and VMAT (182°-178° clockwise) besides new IMRT (8 step-and-shoot fix fields: 225°, 260°, 295°, 330°, 30°, 65°, 90°, 135°) plans were generated per patient. Dose volume histogram parameters were compared between treated VMAT, new IMRT and new optimized hybrid arc plans for OAR doses. Results: The optimized hybrid arc technique revealed significantly lower rectum (p=0.005) and bladder (p= 0.005) doses compared to stand alone VMAT and IMRT. Conclusion: The optimized hybrid arc technique appears to combine the advantages of IMRT and VMAT to provide a more conformal and homogeneous plan with better OAR sparing in comparison to standalone VMAT or IMRT plans.
dc.description.indexedbyTR Dizin
dc.description.issue2
dc.description.publisherscopeNational
dc.description.volume39
dc.identifier.doi10.4274/eamr.galenos.2023.69077
dc.identifier.eissn2651-3153
dc.identifier.issn2651-3137
dc.identifier.quartileN/A
dc.identifier.urihttps://doi.org/10.4274/eamr.galenos.2023.69077
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22308
dc.keywordsVMAT
dc.keywordsIMRT
dc.keywordsHybrid arc
dc.keywordsProstate cancer
dc.languageen
dc.publisherGalenos
dc.sourceEuropean Archives of Medical Research
dc.subjectOncology
dc.subjectProstate cancer
dc.titleOptimized hybrid arc for improved sparing of organs at risk: balanced combination of IMRT and VMAT in prostate cancer
dc.typeJournal article
dspace.entity.typePublication
local.contributor.kuauthorYasemin Bölükbaşı
local.contributor.kuauthorUğur Selek
local.contributor.kuauthorSağlam, Yücel
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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