Publication:
Melatonin as a promising modulator of aging related neurodegenerative disorders: role of micrornas

dc.contributor.coauthorAlamdari, Arezoo Fathalizadeh
dc.contributor.coauthorRahnemayan, Sama
dc.contributor.coauthorVahed, Nafiseh
dc.contributor.coauthorKashani, Hamid Reza Khayat
dc.contributor.coauthorRezabakhsh, Aysa
dc.contributor.coauthorSanaie, Sarvin
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.kuauthorRajabi, Hadi
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2024-11-09T23:39:42Z
dc.date.issued2021
dc.description.abstractOne of the host risk factors involved in aging-related diseases is coupled with the reduction of endogenous melatonin (MLT) synthesis in the pineal gland. MLT is considered a well-known pleiotropic regulatory hormone to modulate a multitude of biological processes such as the regulation of circadian rhythm attended by potent anti-oxidant, anti-inflammatory, and anti-cancer properties. It has also been established that the microRNAs family, as non-coding mRNAs regulating post-transcriptional processes, also serve a crucial role to promote MLT-related advantageous effects in both experimental and clinical settings. Moreover, the anti-aging impact of MLT and miRNAs participation jointly are of particular interest, recently. In this review, we aimed to scrutinize recent advances concerning the therapeutic implications of MLT, particularly in the brain tissue in the face of aging. We also assessed the possible interplay between microRNAs and MLT, which could be considered a therapeutic strategy to slow down the aging process in the nervous system.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume173
dc.identifier.doi10.1016/j.phrs.2021.105839
dc.identifier.eissn1096-1186
dc.identifier.issn1043-6618
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85115246154
dc.identifier.urihttps://doi.org/10.1016/j.phrs.2021.105839
dc.identifier.urihttps://hdl.handle.net/20.500.14288/13164
dc.identifier.wos704159400006
dc.keywordsAging
dc.keywordsElderly patients
dc.keywordsMelatonin
dc.keywordsMicroRNAs
dc.keywordsNeurological disorders
dc.language.isoeng
dc.relation.ispartofPharmacological Research
dc.subjectPharmacology
dc.titleMelatonin as a promising modulator of aging related neurodegenerative disorders: role of micrornas
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorRajabi, Hadi
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2Graduate School of Health Sciences
relation.isOrgUnitOfPublication91bbe15d-017f-446b-b102-ce755523d939
relation.isOrgUnitOfPublication2f870f28-12c9-4b28-9465-b91a69c1d48c
relation.isOrgUnitOfPublication.latestForDiscovery91bbe15d-017f-446b-b102-ce755523d939
relation.isParentOrgUnitOfPublication4c75e0a5-ca7f-4443-bd78-1b473d4f6743
relation.isParentOrgUnitOfPublicationd437580f-9309-4ecb-864a-4af58309d287
relation.isParentOrgUnitOfPublication.latestForDiscovery4c75e0a5-ca7f-4443-bd78-1b473d4f6743

Files