Publication:
Predictive role and clinical value of serum Cytokines in Covid-19

dc.contributor.coauthorBeşli, Yeşim
dc.contributor.departmentKUISCID (Koç University İşbank Center for Infectious Diseases)
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorErgönül, Önder
dc.contributor.kuauthorKeske, Şiran
dc.contributor.kuauthorCan, Füsun
dc.contributor.kuauthorPınarlık, Fatihan
dc.contributor.kuauthorDoğan, Özlem
dc.contributor.kuauthorAlbayrak, Özgür
dc.contributor.kuauthorBabuççu, Gizem
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T20:58:37Z
dc.date.issued2024
dc.description.abstractObjective: Cytokines and chemokines are clinically relevant for severity prediction and treatment of COVID-19 caused by SARS-CoV-2. We aimed to demonstrate the potential cytokines for severity prediction in the five days after symptom onset and describe the importance of serum cytokine levels for patients with different disease severity. Materials and Methods: Hospitalized COVID-19 patients and healthy control participants were recruited, and serial sera were collected from COVID-19 patients. Thirteen cytokines, including interleukin (IL) 1β, interferon (IFN) α2, IFN-γ, tumor necrosis factor (TNF) α, monocyte chemoattractant protein (MCP-1/CCL2), IL-6, IL-8 (CXCL8), IL-10, IL-12p70, IL-17A, IL18, IL-23, and IL-33, were studied by bead-based multiplex assay by flow cytometry. Data regarding routine laboratory test results (leucocyte count, neutrophil count, lymphocyte count, platelet count, hemoglobin, liver transaminases, C-reactive protein [CRP], procalcitonin, and creatinine) were collected. Results: We demonstrated that COVID-19 patients had elevated serum levels of IFN-α2, TNF-α, MCP-1/CCL2, IL-6, IL-8, IL-18, IL-33 compared to healthy participants. Elevated levels of CRP and decreased lymphocyte count were observed in the critical disease group. Longitudinal analysis revealed a statistically significant increase in IL-6, IL-18, and MCP-1 serum levels of critical patients compared to healthy controls. Conclusion: MCP-1, IL-6, and IL-18 were found to be the best predictors of critical COVID-19 disease, and MCP-1 has the highest level of predictive performance. © 2024, DOC Design and Informatics Co. Ltd.. All rights reserved.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.36519/idcm.2024.367
dc.identifier.issn2667-646X
dc.identifier.issue4
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85213347576
dc.identifier.urihttps://doi.org/10.36519/idcm.2024.367
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27517
dc.identifier.volume6
dc.identifier.wos1382580200002
dc.keywordsCovid-19
dc.keywordsCytokine
dc.keywordsIl-6
dc.keywordsMcp-1
dc.keywordsSeverity prediction
dc.language.isoeng
dc.publisherDOC Design and Informatics Co. Ltd.
dc.relation.ispartofInfectious Diseases and Clinical Microbiology
dc.subjectMedicine
dc.titlePredictive role and clinical value of serum Cytokines in Covid-19
dc.typeJournal Article
dspace.entity.typePublication
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1Research Center
local.publication.orgunit2KUISCID (Koç University İşbank Center for Infectious Diseases)
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
local.publication.orgunit2Graduate School of Sciences and Engineering
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