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Progestin-primed ovarian stimulation for oocyte/embryo freezing is not inferior to GnRH antagonist cycles in cancer patients for ovarian response and IVF characteristics

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dc.contributor.departmentSchool of Medicine
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.kuauthorPhD Student, Benlioğlu, Can
dc.contributor.kuauthorDoctor, Keleş, İpek
dc.contributor.kuauthorFaculty Member, Ata, Mustafa Barış
dc.contributor.kuauthorFaculty Member, Öktem, Özgür
dc.contributor.kuauthorPhD Student, Savaş, İklim Doğa
dc.contributor.kuauthorPhD Student, Pirmoradi, Samaneh
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.date.accessioned2025-09-10T04:55:49Z
dc.date.available2025-09-09
dc.date.issued2025
dc.description.abstractAbstract Study question Does progestin-priming ovarian stimulation be an alternative to GnRH antagonist cycles in cancer patients for oocyte/embryo freezing? Summary answer Yes, PPOS is not inferior to antagonist cycles in terms of oocyte yield, maturation, fertilization, cleavage, blastulation, or good-quality embryo formation rates. What is known already There has been an expanding use of PPOS cycles, especially with the increasing utilization of freeze-all cycles as a simple-to-administer and less expensive alternative to GnRH analogs in routine IVF practice. Very limited data is available regarding the use of this stimulation protocol in cancer patients for oocyte/embryo freezing. We aimed to address this issue in the current study. Study design, size, duration A retrospective cohort study was conducted between 2018 and 2024 at a tertiary fertility center, evaluating 92 female cancer patients who underwent 105 ovarian stimulation cycles for fertility preservation. Patients were stimulated using either progestin-primed ovarian stimulation (PPOS, n = 35) or a GnRH antagonist protocol (n = 70).
dc.description.fulltextNo
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dc.description.indexedbyWOS
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume40
dc.identifier.doi10.1093/humrep/deaf097.691
dc.identifier.eissn1460-2350
dc.identifier.embargoNo
dc.identifier.issn0268-1161
dc.identifier.quartileQ1
dc.identifier.urihttps://doi.org/10.1093/humrep/deaf097.691
dc.identifier.urihttps://hdl.handle.net/20.500.14288/30108
dc.identifier.wos001513206200023
dc.language.isoeng
dc.publisherOxford Univ Press
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofHuman Reproduction
dc.subjectObstetrics and gynecology
dc.subjectReproductive biology
dc.titleProgestin-primed ovarian stimulation for oocyte/embryo freezing is not inferior to GnRH antagonist cycles in cancer patients for ovarian response and IVF characteristics
dc.typeMeeting Abstract
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