Publication:
Cytokine profile in patients with maturity-onset diabetes of the young (MODY)

dc.contributor.coauthorDiren, A.
dc.contributor.coauthorDemirci, D.K.
dc.contributor.coauthorGül, N.
dc.contributor.coauthorKaracanlı, B.
dc.contributor.coauthorBaykut, A.
dc.contributor.coauthorÖztürk, O.
dc.contributor.coauthorSatman, I.
dc.contributor.coauthorYılmaz Aydoğan, H.
dc.contributor.kuauthorTütüncü, Yıldız
dc.contributor.kuprofileFaculty Member
dc.contributor.yokid239430
dc.date.accessioned2024-11-09T11:48:50Z
dc.date.issued2022
dc.description.abstractBackground/aim: high-sensitivity C-reactive protein (hs-CRP) is used in the differential diagnosis of maturity-onset diabetes of the young (MODY)-3, but other inflammatory markers have not been investigated in MODY patients. We aimed to compare the serum levels of anti-inflammatory and proinflammatory cytokines between MODY patients and healthy subjects and show the inflammatory features in MODY subtypes. Patients and methods: thirty patients with clinically suspected MODY and 34 healthy controls were included in this study. Next -generation sequencing (NGS) was used for the molecular diagnosis of MODY subtypes. Serum levels of cytokines were measured using a multiplexed cytokine assay and hs-CRP concentration was determined by the immunoturbidimetric assay. Results: the hs-CRP levels were higher in both NGS-confirmed (MODY, n=17) (p=0.009) and NGS-unconfirmed (non-MODY, n=13) patients (p<0.001) than those in controls. However, IL-1 beta (p=0.001), IL-6 (p=0.018), IL-31 (p=0.003), TNF-alpha (p<0.001), and sCD40L (p=0.007) levels of MODY patients and IL-1 beta (p=0.002), IL-31 (p<0.001), IL-22 (p=0.018), and sCD40L (p=0.039) levels of non-MODY patients were lower than those of controls. While hs-CRP levels were lower in MODY3 patients than non-MODY3 patients (p=0.009), IL-17A (p=0.006) and IL-23 (p=0.016) levels for the first time in this study were found to be higher in patients with MODY3 than in patients with other MODY subtypes (p<0.05). Conclusion: MODY patients had lower serum levels of the proinflammatory cytokines IL-1 beta, IL-6, TNF-alpha, IL-31, and sCD40L compared to healthy controls. High IL-17A and IL-23 levels along with low hs-CRP levels may be potential markers to distinguish MODY3 from other MODY subtypes.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue5
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThis study was supported by the Scientific Research Fund of Istanbul University within the scope of the project entitled “Investigation of Inflammatory Cytokine Profile in Maturity-Onset Diabetes of the Young (MODY)” (Project no. TSA-2017-25335). The Authors thank their patients and healthy control subjects who participated in the study
dc.description.versionPublisher version
dc.description.volume36
dc.formatpdf
dc.identifier.doi10.21873/invivo.12985
dc.identifier.eissn1791-7549
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03961
dc.identifier.issn0258-851X
dc.identifier.linkhttps://doi.org/10.21873/invivo.12985
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85138446312
dc.identifier.urihttps://hdl.handle.net/20.500.14288/623
dc.identifier.wos878903300009
dc.keywordsPro-inflammatory cytokines
dc.keywordsHs-CRP
dc.keywordsHbA1c
dc.keywordsMODY
dc.keywordsMODY3
dc.keywordsDiabetes
dc.languageEnglish
dc.publisherHighWire Press
dc.relation.grantnoNA
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10849
dc.sourceIn Vivo
dc.subjectResearch and experimental medicine
dc.titleCytokine profile in patients with maturity-onset diabetes of the young (MODY)
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0002-3905-6429
local.contributor.kuauthorTütüncü, Yıldız
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine

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