Publication:
Theories and molecular basis of vascular aging: a review of the literature from VascAgeNet Group on pathophysiological mechanisms of vascular aging

dc.contributor.coauthorGkaliagkousi, Eugenia
dc.contributor.coauthorLazaridis, Antonios
dc.contributor.coauthorDoğan, Soner
dc.contributor.coauthorFraenkel, Emil
dc.contributor.coauthorTuna, Bilge Güvenç
dc.contributor.coauthorMozos, Ioana
dc.contributor.coauthorVukicevic, Milica
dc.contributor.coauthorGopcevic, Kristina
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorYalçın, Özlem
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T12:15:55Z
dc.date.issued2022
dc.description.abstractVascular aging, characterized by structural and functional alterations of the vascular wall, is a hallmark of aging and is tightly related to the development of cardiovascular mortality and age-associated vascular pathologies. Over the last years, extensive and ongoing research has highlighted several sophisticated molecular mechanisms that are involved in the pathophysiology of vascular aging. A more thorough understanding of these mechanisms could help to provide a new insight into the complex biology of this non-reversible vascular process and direct future interventions to improve longevity. In this review, we discuss the role of the most important molecular pathways involved in vascular ageing including oxidative stress, vascular inflammation, extracellular matrix metalloproteinases activity, epigenetic regulation, telomere shortening, senescence and autophagy.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue15
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume23
dc.identifier.doi10.3390/ijms23158672
dc.identifier.eissn1422-0067
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03809
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85136342796
dc.identifier.urihttps://hdl.handle.net/20.500.14288/1363
dc.identifier.wos839094700001
dc.keywordsVascular aging
dc.keywordsInflammation
dc.keywordsAtherosclerosis
dc.keywordsMatrix metalloproteinases
dc.keywordsOxidative stress
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.grantnoNA
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10666
dc.subjectBiochemistry and molecular biology
dc.subjectChemistry, multidisciplinary
dc.titleTheories and molecular basis of vascular aging: a review of the literature from VascAgeNet Group on pathophysiological mechanisms of vascular aging
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorYalçın, Özlem
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
10666.pdf
Size:
1.15 MB
Format:
Adobe Portable Document Format