Publication: New missions for an old agent: granulocyte-colony stimulating factor in the treatment of stroke patients
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Digiçaylıoğlu, Murat
Zhang, John H.
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Abstract
Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, anti-oxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.
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Bentham Science Publishers
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Current Medicinal Chemistry
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10.2174/0929867322666150209153606
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