Publication:
New missions for an old agent: granulocyte-colony stimulating factor in the treatment of stroke patients

Placeholder

Departments

Organizational Unit

School / College / Institute

Organizational Unit
SCHOOL OF MEDICINE
Upper Org Unit

Program

KU Authors

Co-Authors

Digiçaylıoğlu, Murat
Zhang, John H.

Publication Date

Language

Embargo Status

Journal Title

Journal ISSN

Volume Title

Alternative Title

Abstract

Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, anti-oxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.

Source

Publisher

Bentham Science Publ Ltd

Subject

Biochemistry, Molecular biology, Clinical chemistry, Pharmacology, Pharmacy

Citation

Has Part

Source

Current Medicinal Chemistry

Book Series Title

Edition

DOI

10.2174/0929867322666150209153606

item.page.datauri

Link

Rights

Copyrights Note

Endorsement

Review

Supplemented By

Referenced By

0

Views

0

Downloads

View PlumX Details