Publication: New missions for an old agent: granulocyte-colony stimulating factor in the treatment of stroke patients
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KU-Authors
KU Authors
Co-Authors
Digiçaylıoğlu, Murat
Zhang, John H.
Publication Date
Language
Type
Embargo Status
Journal Title
Journal ISSN
Volume Title
Alternative Title
Abstract
Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, anti-oxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.
Source
Publisher
Bentham Science Publ Ltd
Subject
Biochemistry, Molecular biology, Clinical chemistry, Pharmacology, Pharmacy
Citation
Has Part
Source
Current Medicinal Chemistry
Book Series Title
Edition
DOI
10.2174/0929867322666150209153606