Publication:
New missions for an old agent: granulocyte-colony stimulating factor in the treatment of stroke patients

Simple item page
dc.contributor.coauthorDigiçaylıoğlu, Murat
dc.contributor.coauthorZhang, John H.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKeleş, Güven Evren
dc.contributor.kuauthorSolaroğlu, İhsan
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:58:44Z
dc.date.issued2015
dc.description.abstractGranulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, anti-oxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue10
dc.description.openaccessNO
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume22
dc.identifier.doi10.2174/0929867322666150209153606
dc.identifier.eissn1875-533X
dc.identifier.issn0929-8673
dc.identifier.scopus2-s2.0-84931269931
dc.identifier.urihttps://doi.org/10.2174/0929867322666150209153606
dc.identifier.urihttps://hdl.handle.net/20.500.14288/15520
dc.identifier.wos351160400013
dc.keywordsGranulocyte-colony stimulating factor
dc.keywordsNeuroprotection
dc.keywordsStroke
dc.keywordstreatment
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Medicinal Chemistry
dc.subjectBiochemistry
dc.subjectMolecular biology
dc.subjectClinical chemistry
dc.subjectPharmacology
dc.subjectPharmacy
dc.titleNew missions for an old agent: granulocyte-colony stimulating factor in the treatment of stroke patients
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorSolaroğlu, İhsan
local.contributor.kuauthorKeleş, Güven Evren
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

Files

Collections

Publications without Fulltext