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Zoledronate-responsive calcitriol-mediated hypercalcemia in a 5-year-old case with squamous cell carcinoma on the background of xeroderma pigmentosum

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dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBörklü Yücel, Esra
dc.contributor.kuauthorHatun, Şükrü
dc.contributor.kuauthorKayserili, Hülya
dc.contributor.kuauthorSözmen, Banu Oflaz
dc.contributor.kuauthorYeşiltepe Mutlu, Rahime Gül
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T12:25:56Z
dc.date.issued2019
dc.description.abstractMalignancy-induced hypercalcemia is a very rare condition in children whereas it is more common among adult patients with malignancy. The mechanisms of malignancy-induced hypercalcemia include the over-secretion of parathyroid hormone-related protein (PTHrP), osteolytic metastases and the over-production of 1,25-dihydroxyvitamin D (calcitriol). Although hypercalcemia due to PTHrP secretion has been published before, overproduction of calcitriol has not been reported yet in pediatric squamous cell skin carcinoma cases. Herein, we report calcitriol-mediated severe hypercalcemia in a 5-year-old boy with squamous cell skin carcinoma arising in the background of xeroderma pigmentosum (XP) which responded well to zoledronate treatment. To the best of our knowledge, this is the first pediatric case of malignancy-induced hypercalcemia which is mediated by calcitriol in squamous cell skin carcinoma.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue12
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume32
dc.identifier.doi10.1515/jpem-2019-0158
dc.identifier.eissn2191-0251
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR02443
dc.identifier.issn0334-018X
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-85075960115
dc.identifier.urihttps://hdl.handle.net/20.500.14288/1638
dc.identifier.wos499700200014
dc.keywordsHypercalcemia
dc.keywordsXeroderma pigmentosum
dc.keywordsZoledronic acid
dc.language.isoeng
dc.publisherDe Gruyter
dc.relation.grantnoNA
dc.relation.ispartofJournal of Pediatric Endocrinology and Metabolism
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9080
dc.subjectMedicine
dc.subjectEndocrinology and metabolism
dc.subjectPediatrics
dc.titleZoledronate-responsive calcitriol-mediated hypercalcemia in a 5-year-old case with squamous cell carcinoma on the background of xeroderma pigmentosum
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorYeşiltepe Mutlu, Rahime Gül
local.contributor.kuauthorHatun, Şükrü
local.contributor.kuauthorÇolak, Ülkem
local.contributor.kuauthorSözmen, Banu Oflaz
local.contributor.kuauthorBörklü Yücel, Esra
local.contributor.kuauthorKayserili, Hülya
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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