Publication: Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy
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Program
KU-Authors
KU Authors
Co-Authors
Prasad, S.
Blakeway, H.
Townsend, R.
O’Brien, P.
Morris, E.
Draycott, T.
Thangaratinam, S.
Le Doare, K.
Ladhani, S.
von Dadelszen, P.
Advisor
Publication Date
2022
Language
English
Type
Review
Journal Title
Journal ISSN
Volume Title
Abstract
Safety and effectiveness of COVID-19 vaccines during pregnancy is a particular concern affecting vaccination uptake by this vulnerable group. Here we evaluated evidence from 23 studies including 117,552 COVID-19 vaccinated pregnant people, almost exclusively with mRNA vaccines. We show that the effectiveness of mRNA vaccination against RT-PCR confirmed SARS-CoV-2 infection 7 days after second dose was 89 center dot 5% (95% CI 69 center dot 0-96 center dot 4%, 18,828 vaccinated pregnant people, I-2 = 73 center dot 9%). The risk of stillbirth was significantly lower in the vaccinated cohort by 15% (pooled OR 0 center dot 85; 95% CI 0 center dot 73-0 center dot 99, 66,067 vaccinated vs. 424,624 unvaccinated, I-2 = 93 center dot 9%). There was no evidence of a higher risk of adverse outcomes including miscarriage, earlier gestation at birth, placental abruption, pulmonary embolism, postpartum haemorrhage, maternal death, intensive care unit admission, lower birthweight Z-score, or neonatal intensive care unit admission (p > 0.05 for all). COVID-19 mRNA vaccination in pregnancy appears to be safe and is associated with a reduction in stillbirth. Pregnant women have been disproportionately under-vaccinated against COVID-19, partly because they were excluded from initial trials. This systematic review and meta-analysis supports efficacy of vaccination in pregnancy, and finds no evidence of adverse maternal or perinatal outcomes.
Description
Source:
Nature Communications
Publisher:
Springer Nature
Keywords:
Subject
Science and technology