Publication: Plasma membrane regulates ras signaling networks
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KU Authors
Co-Authors
Chavan, Tanmay Sanjeev
Marszalek, Richard
Jang, Hyunbum
Nussinov, Ruth
Gaponenko, Vadim
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Embargo Status
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Abstract
Ras GTPases activate more than 20 signaling pathways, regulating such essential cellular functions as proliferation, survival, and migration. How Ras proteins control their signaling diversity is still a mystery. Several pieces of evidence suggest that the plasma membrane plays a critical role. Among these are: (1) selective recruitment of Ras and its effectors to particular localities allowing access to Ras regulators and effectors; (2) specific membrane-induced conformational changes promoting Ras functional diversity; and (3) oligomerization of membrane-anchored Ras to recruit and activate Raf. Taken together, the membrane does not only attract and retain Ras but also is a key regulator of Ras signaling. This can already be gleaned from the large variability in the sequences of Ras membrane targeting domains, suggesting that localization, environment and orientation are important factors in optimizing the function of Ras isoforms.
Source
Publisher
Taylor & Francis
Subject
Cell physiological phenomena
Citation
Has Part
Source
Cellular Logistics
Book Series Title
Edition
DOI
10.1080/21592799.2015.1136374