Publication:
Molecular and immunohistochemical analysis of mucinous cystic neoplasm of the liver

dc.contributor.coauthorVan Treeck, Benjamin J.
dc.contributor.coauthorLotfalla, Mira
dc.contributor.coauthorCzeczok, Thomas W.
dc.contributor.coauthorMounajjed, Taofic
dc.contributor.coauthorMoreira, Roger K.
dc.contributor.coauthorAllende, Daniela S.
dc.contributor.coauthorReid, Michelle D.
dc.contributor.coauthorNaini, Bita, V
dc.contributor.coauthorWesterhoff, Maria
dc.contributor.coauthorKerr, Sarah E.
dc.contributor.coauthorRizvi, Sumera H.
dc.contributor.coauthorSmoot, Rory L.
dc.contributor.coauthorLiu, Yuanhang
dc.contributor.coauthorDavila, Jaime
dc.contributor.coauthorGraham, Rondell P.
dc.contributor.departmentN/A
dc.contributor.kuauthorAdsay, Nazmi Volkan
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.yokid286248
dc.date.accessioned2024-11-09T22:45:40Z
dc.date.issued2020
dc.description.abstractObjectives: Mucinous cystic neoplasm of the liver is characterized by neoplastic mucinous andl or biliary epithelium surrounded by ovarian-type stroma. Immunohistochemical studies have shown that the ovarian-type stroma expresses estrogen receptor, suggesting potential hormonal responsiveness. The molecular biology of mucinous cystic neoplasm of the liver remains poorly studied Methods: Transcriptome sequencing and immunohistochemistry were performed on a series of mucinous cystic neoplasms. Results: Mucinous cystic neoplasm of the liver exhibited significantly increased RNA expression of ovarian stromal markers WT1, PR, and ER2 and sex cord stromal markers SF-1, inhibin-alpha, and calretinin compared with nonneoplastic liver. Immunohistochemistry confirmed the RNA-level data. Evidence for sex hormone biosynthesis was identified by significant overexpression of multiple estrogen biosynthetic enzymes. Expression of I 7 beta-hydroxysteroid dehydrogenase 1 was confirmed immunohistochemically. Pathway analysis also identified significant upregulation of the hedgehog and Win pathways and significant downregulation of T-helper 1 and T-helper 2 pathways. Conclusions: Mucinous cystic neoplasm of the liver recapitulates ovarian stroma at the morphologic, DNA, RNA, and protein levels. These data support the concept that this tumor likely arises from ectopic primitive gonadal tissue andl or stromal cells with capacity to transdifferentiate to ovarian cortical cells.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue6
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsorshipNCI NIH HHS [K08 CA236874] Funding Source: Medline
dc.description.volume154
dc.identifier.doi10.1093/ajcp/aqaa115
dc.identifier.eissn1943-7722
dc.identifier.issn0002-9173
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85095669668
dc.identifier.urihttp://dx.doi.org/10.1093/ajcp/aqaa115
dc.identifier.urihttps://hdl.handle.net/20.500.14288/6139
dc.identifier.wos592533000014
dc.keywordsMucinous cystic neoplasm
dc.keywordsHedgehog pathway
dc.keywordsOvarian-like stroma
dc.keywordsBiliary neoplasia ovarian-type stroma
dc.languageEnglish
dc.publisherOxford University Press (OUP)
dc.sourceAmerican Journal of Clinical Pathology
dc.subjectPathology
dc.titleMolecular and immunohistochemical analysis of mucinous cystic neoplasm of the liver
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0002-1308-3701
local.contributor.kuauthorAdsay, Nazmi Volkan

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