Publication:
Urinary biomarkers in the early detection and follow-up of tubular injury in childhood urolithiasis

dc.contributor.coauthorFuçucuoğlu, Dilara
dc.contributor.coauthorKüçük, Suat Hayri
dc.contributor.coauthorErol, Meltem
dc.contributor.coauthorYiğit, Özgül
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorBilge, İlmay
dc.contributor.kuauthorTaşdemir, Mehmet
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:19:24Z
dc.date.issued2018
dc.description.abstractBackground: To investigate relationships among urinary biomarkers [kidney injury molecule-1 (KIM-1), N-acetyl-β-glucosaminidase (NAG)], neutrophil gelatinase-associated lipocalin (NGAL) levels and renal tubular injury in childhood urolithiasis. Methods: Seventy children [36 girls, mean age: 7.3 ± 5.0 years (0.5–18.2)] with urolithiasis/microlithiasis and 42 controls [18 girls, mean age: 8.5 ± 3.8 years (0.9–16.2)] were included in this multicenter, controlled, prospective cohort study. Patients were evaluated three times in 6-month intervals (0, 6 and 12th months). Anthropometric data, urinary symptoms, family history and diagnostic studies were recorded. Urine samples were analyzed for metabolic risk factors (urinary calcium, uric acid, oxalate, citrate, cystine, magnesium, and creatinine excretion), and the urinary KIM-1, NAG, and NGAL levels were measured. Results: Stones were mostly located in the upper urinary system (82.9%), and six patients (8.6%) had hydronephrosis. Thirty patients (42.9%) had several metabolic risk factors, and the most common metabolic risk factor was hypocitraturia (22.9%). Urinary KIM-1/Cr, NAG/Cr and NGAL/Cr ratios were not significantly different between patients and controls. Furthermore, no significant changes in their excretion were shown during follow-up. Notably, the urinary KIM-1/Cr, NAG/Cr, and NGAL/Cr levels were significantly higher in children under 2 years of age (p = 0.011, p = 0.006, and 0.015, respectively). NAG/Cr and NGAL/Cr ratios were significantly increased in patients with hydronephrosis (n = 6, p = 0.031 and 0.023, respectively). Conclusions: The results of this study suggest that none of the aforementioned urinary biomarkers (KIM-1, NAG and NGAL levels) may be useful for the early detection and/or follow-up of renal tubular injury and/or dysfunction in childhood urolithiasis.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume22
dc.identifier.doi10.1007/s10157-017-1436-3
dc.identifier.eissn1437-7799
dc.identifier.issn1342-1751
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85021283021
dc.identifier.urihttps://doi.org/10.1007/s10157-017-1436-3
dc.identifier.urihttps://hdl.handle.net/20.500.14288/10547
dc.identifier.wos424640300017
dc.keywordsKidney stone disease
dc.keywordsBiomarkers
dc.keywordsMetabolic abnormalities
dc.keywordsKidney injury molecule-1
dc.keywordsN-acetyl-beta-glucosaminidase
dc.keywordsNeutrophil gelatinase-associated lipocalin
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofClinical and Experimental Nephrology
dc.subjectUrology
dc.subjectNephrology
dc.titleUrinary biomarkers in the early detection and follow-up of tubular injury in childhood urolithiasis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTaşdemir, Mehmet
local.contributor.kuauthorBilge, İlmay
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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