Publication:
Conditional survival after radical cystectomy for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder: a population-based analysis

dc.contributor.coauthorBarletta, Francesco
dc.contributor.coauthorTappero, Stefano
dc.contributor.coauthorPanunzio, Andrea
dc.contributor.coauthorIncesu, Reha-Baris
dc.contributor.coauthorGarcia, Cristina Cano
dc.contributor.coauthorPiccinelli, Mattia Luca
dc.contributor.coauthorTian, The
dc.contributor.coauthorGandaglia, Giorgio
dc.contributor.coauthorMoschini, Marco
dc.contributor.coauthorTerrone, Carlo
dc.contributor.coauthorAntonelli, Alessandro
dc.contributor.coauthorChun, Felix K. H.
dc.contributor.coauthorDe Cobelli, Ottavio
dc.contributor.coauthorSaad, Fred
dc.contributor.coauthorShariat, Shahrokh F.
dc.contributor.coauthorMontorsi, Francesco
dc.contributor.coauthorBriganti, Alberto
dc.contributor.coauthorKarakiewicz, Pierre I.
dc.contributor.kuauthorTilki, Derya
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.unitKoç University Hospital
dc.date.accessioned2024-12-29T09:40:53Z
dc.date.issued2023
dc.description.abstractPurpose: To assess the effect of event-free survival duration on cancer-specific mortality (CSM) after radical cystectomy (RC) in nonmetastatic muscle-invasive squamous cell carcinoma of the urinary bladder. Methods: RC patients treated for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder were identified within the Surveillance, Epidemiology, and End Results database (2000-2018). Independent predictor status for CSM of T and N stage groupings (i.e., T2N0, T3N0, T4N0, and TanyN1-3) was tested in multivariable Cox-regression models. Conditional 5-year CSM-free estimates were assessed at baseline and at 4 specific event-free survival times (i.e. 6, 12, 18 and 24 months), within each of the 4 examined stage groups. Results: Of 981 RC patients, 206 (21%), 416 (42%), 152 (16%), and 207 (21%) were T2N0, T3N0, T4N0, and TanyN1-3, respectively. In multivariable Cox-regression models T3N0 (HR 1.94), T4N0 (HR 5.22), and TanyN1-3 (HR 6.62) were independent predictors of CSM, relative to T2N0. In conditional survival analyses based on 24 months event-free status, survival estimates were: 89% for T2N0 vs. 76% at baseline (Delta = 13%), 84% for T3N0 vs. 58% at baseline (Delta = 26%), 69% for T4N0 vs. 25% at baseline (Delta = 44%), 69% for TanyN1-3 vs. 22% at baseline (Delta = 47%). Conclusions: Event-free status at 24 months of follow-up is associated with substantially higher CSM-free survival than when CSM-free survival is predicted at baseline. The magnitude of this effect is most pronounced in TanyN1-3 and T4N0 patients, intermediate in T3N0 and more modest, nonetheless important, in T2N0.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.publisherscopeInternational
dc.description.volume41
dc.identifier.doi10.1016/j.urolonc.2022.10.027
dc.identifier.eissn1873-2496
dc.identifier.issn1078-1439
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85142500837
dc.identifier.urihttps://doi.org/10.1016/j.urolonc.2022.10.027
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23475
dc.identifier.wos994518000001
dc.keywordsSEER program
dc.keywordsBladder cancer
dc.keywordsCystectomy
dc.keywordsHistological variant
dc.keywordsSquamous cell carcinoma
dc.keywordsConditional survival
dc.languageen
dc.publisherElsevier Science Inc
dc.sourceUrologic Oncology-Seminars and Original Investigations
dc.subjectOncology
dc.subjectUrology
dc.subjectNephrology
dc.titleConditional survival after radical cystectomy for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder: a population-based analysis
dc.typeJournal article
dspace.entity.typePublication
local.contributor.kuauthorTilki, Derya

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