Publication: Conditional survival after radical cystectomy for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder: a population-based analysis
dc.contributor.coauthor | Barletta, Francesco | |
dc.contributor.coauthor | Tappero, Stefano | |
dc.contributor.coauthor | Panunzio, Andrea | |
dc.contributor.coauthor | Incesu, Reha-Baris | |
dc.contributor.coauthor | Garcia, Cristina Cano | |
dc.contributor.coauthor | Piccinelli, Mattia Luca | |
dc.contributor.coauthor | Tian, The | |
dc.contributor.coauthor | Gandaglia, Giorgio | |
dc.contributor.coauthor | Moschini, Marco | |
dc.contributor.coauthor | Terrone, Carlo | |
dc.contributor.coauthor | Antonelli, Alessandro | |
dc.contributor.coauthor | Chun, Felix K. H. | |
dc.contributor.coauthor | De Cobelli, Ottavio | |
dc.contributor.coauthor | Saad, Fred | |
dc.contributor.coauthor | Shariat, Shahrokh F. | |
dc.contributor.coauthor | Montorsi, Francesco | |
dc.contributor.coauthor | Briganti, Alberto | |
dc.contributor.coauthor | Karakiewicz, Pierre I. | |
dc.contributor.kuauthor | Tilki, Derya | |
dc.contributor.schoolcollegeinstitute | School of Medicine | |
dc.contributor.unit | Koç University Hospital | |
dc.date.accessioned | 2024-12-29T09:40:53Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Purpose: To assess the effect of event-free survival duration on cancer-specific mortality (CSM) after radical cystectomy (RC) in nonmetastatic muscle-invasive squamous cell carcinoma of the urinary bladder. Methods: RC patients treated for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder were identified within the Surveillance, Epidemiology, and End Results database (2000-2018). Independent predictor status for CSM of T and N stage groupings (i.e., T2N0, T3N0, T4N0, and TanyN1-3) was tested in multivariable Cox-regression models. Conditional 5-year CSM-free estimates were assessed at baseline and at 4 specific event-free survival times (i.e. 6, 12, 18 and 24 months), within each of the 4 examined stage groups. Results: Of 981 RC patients, 206 (21%), 416 (42%), 152 (16%), and 207 (21%) were T2N0, T3N0, T4N0, and TanyN1-3, respectively. In multivariable Cox-regression models T3N0 (HR 1.94), T4N0 (HR 5.22), and TanyN1-3 (HR 6.62) were independent predictors of CSM, relative to T2N0. In conditional survival analyses based on 24 months event-free status, survival estimates were: 89% for T2N0 vs. 76% at baseline (Delta = 13%), 84% for T3N0 vs. 58% at baseline (Delta = 26%), 69% for T4N0 vs. 25% at baseline (Delta = 44%), 69% for TanyN1-3 vs. 22% at baseline (Delta = 47%). Conclusions: Event-free status at 24 months of follow-up is associated with substantially higher CSM-free survival than when CSM-free survival is predicted at baseline. The magnitude of this effect is most pronounced in TanyN1-3 and T4N0 patients, intermediate in T3N0 and more modest, nonetheless important, in T2N0. | |
dc.description.indexedby | WoS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 3 | |
dc.description.publisherscope | International | |
dc.description.volume | 41 | |
dc.identifier.doi | 10.1016/j.urolonc.2022.10.027 | |
dc.identifier.eissn | 1873-2496 | |
dc.identifier.issn | 1078-1439 | |
dc.identifier.quartile | Q2 | |
dc.identifier.scopus | 2-s2.0-85142500837 | |
dc.identifier.uri | https://doi.org/10.1016/j.urolonc.2022.10.027 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/23475 | |
dc.identifier.wos | 994518000001 | |
dc.keywords | SEER program | |
dc.keywords | Bladder cancer | |
dc.keywords | Cystectomy | |
dc.keywords | Histological variant | |
dc.keywords | Squamous cell carcinoma | |
dc.keywords | Conditional survival | |
dc.language | en | |
dc.publisher | Elsevier Science Inc | |
dc.source | Urologic Oncology-Seminars and Original Investigations | |
dc.subject | Oncology | |
dc.subject | Urology | |
dc.subject | Nephrology | |
dc.title | Conditional survival after radical cystectomy for non-metastatic muscle-invasive squamous cell carcinoma of the urinary bladder: a population-based analysis | |
dc.type | Journal article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Tilki, Derya |