Alfentanil use in rapid sequence induction

Abstract

Objective: In our study, the effects of using different doses of alfentanil on intubation conditions and hemody-namic parameters were investigated to provide rapid-sequence intubation (RSI) conditions. Materials and Methods: Fifty-six female patients between the ages of 24–73 who would undergo a medium surgical procedure with a risk of ASA I-II were divided into two groups of 28 each. Intravenous anesthetic and rocuronium doses were standardized for anesthesia induction, and 3 μg/kg alfentanil was given to Group I and 10 μg/kg alfentanil to Group II for anesthesia induction. Furthermore, after intuba-tion, inhalation anesthesia was standardized, electrocardi- ography, non-invasive-blood-pressure, peripheral oxygen saturation, end-tidal carbon dioxide, and inspiratory sevoflurane concentration, temperature, and train-of-four (TOF) monitoring were performed. All patients were intubated at 60 s and monitorization was recorded until the 10th min (1st-2nd-3rd-4th-5th-7th-10th min) and after skin incision. Results: We found no significant differences between the two groups according to intubation scores and TOF scores (p=0.052, all p’s>0.39, respectively). How- ever, all measured mean-arterial blood pressure values were lower in Group II (all p’s<0.012). When the heart rate (HR) of the groups were compared, it was found that Group II was not statistically different from the baseline value (all p’s>82) at the 3rd min and after intubation, but HRs of Group I were higher than the baseline HR (all p’s<0.32) were observed. Conclusion: It was observed that the use of alfentanil at a dose of 10 μg/kg in RSI improved hemodynamic parameters without affecting the intubation con- ditions compared to the use of 3 μg/kg in RSI.