Publication:
Morphometric differences in planum temporale in schizophrenia and bipolar disorder revealed by statistical analysis of labeled cortical depth maps

dc.contributor.coauthorRatnanather, J. Tilak
dc.contributor.coauthorCebron, Shannon
dc.contributor.coauthorPostell, Elizabeth
dc.contributor.coauthorPisano, Dominic V.
dc.contributor.coauthorPoynton, Clare B.
dc.contributor.coauthorCrocker, Britni
dc.contributor.coauthorHoneycutt, Nancy A.
dc.contributor.coauthorMahon, Pamela B.
dc.contributor.coauthorBarta, Patrick E.
dc.contributor.departmentDepartment of Mathematics
dc.contributor.kuauthorCeyhan, Elvan
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.date.accessioned2024-11-09T12:25:59Z
dc.date.issued2015
dc.description.abstractDifferences in cortical thickness in the lateral temporal lobe, including the planum temporale (PT), have been reported in MRI studies of schizophrenia (SCZ) and bipolar disorder (BPD) patients. Most of these studies have used a single-valued global or local measure for thickness. However, additional and complementary information can be obtained by generating labeled cortical distance maps (LCDMs), which are distances of labeled gray matter (GM) voxels from the nearest point on the GM/white matter (WM) (inner) cortical surface. Statistical analyses of pooled and censored LCDM distances reveal subtle differences in PT between SCZ and BPD groups from data generated by Ratnanather et al. (Schizophrenia Research, https://doi.org/10.1016/j.schres.2013.08.014). These results confirm that the left planum temporale (LPT) is more sensitive than the right PT in distinguishing between SCZ, BPD, and healthy controls. Also confirmed is a strong gender effect, with a thicker PT seen in males than in females. The differences between groups at smaller distances in the LPT revealed by pooled and censored LCDM analysis suggest that SCZ and BPD have different effects on the cortical mantle close to the GM/WM surface. This is consistent with reported subtle changes in the cortical mantle observed in post-mortem studies.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2&3
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipEC under the Marie Curie IOF Programme
dc.description.versionPublisher version
dc.description.volume150
dc.identifier.doi10.1016/j.schres.2013.08.014
dc.identifier.eissn1664-0640
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR00148
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-84886245317
dc.identifier.urihttps://doi.org/10.1016/j.schres.2013.08.014
dc.identifier.wos326180700025
dc.keywordsBipolar disorder
dc.keywordsCortical mantle
dc.keywordsCortical thickness
dc.keywordsPlanum temporale
dc.keywordsSchizophrenia
dc.language.isoeng
dc.publisherFrontiers
dc.relation.grantnoR01 MH064838
dc.relation.grantnoR01 EB000975
dc.relation.grantnoP41 EB015909
dc.relation.grantno329370 PRinHDD
dc.relation.ispartofFrontiers in Psychiatry
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/1179
dc.subjectPsychiatry
dc.titleMorphometric differences in planum temporale in schizophrenia and bipolar disorder revealed by statistical analysis of labeled cortical depth maps
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorCeyhan, Elvan
local.publication.orgunit1College of Sciences
local.publication.orgunit2Department of Mathematics
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