Publication:
Visible-light-induced synthesis of pH-responsive composite hydrogels for controlled delivery of the anticonvulsant drug pregabalin

dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.kuauthorGidon, Doğan
dc.contributor.kuauthorKızılel, Seda
dc.contributor.kuauthorÇevik, Özlem
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.date.accessioned2024-11-09T23:14:07Z
dc.date.issued2015
dc.description.abstractWe report here a novel method for the synthesis of a pH-responsive composite using visible light. Formation of the pH-responsive layer is based on poly(methacrylic acid-g-ethylene glycol) as the macromer, eosin Y as the photoinitiator and triethanolamine as the co-initiator. The hydrogel was functionalized with hydrophobic domains through incorporation of crosslinked styrene-butadiene-styrene (SBS) copolymer into the pH-responsive prepolymer. Swelling ratios were decreased with the addition of SBS, and resulted in high hydrogel crosslink density. The composite allowed for controlled release of an anticonvulsant model drug, pregabalin, under neutral pH condition and the release was analyzed to describe the mode of transport through the network. In vitro human fibroblast survival assay and in vivo rabbit implantation experiments demonstrated that this hybrid network is not toxic and has desirable biocompatibility properties. This is the first report about the synthesis of a pH-responsive network incorporating crosslinked SBS synthesized under visible light. The approach for multifunctional membranes could allow the incorporation of molecules with specific functionalities so that sequential molecule delivery in response to specific stimuli could be achieved. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipMarie Curie Reintegration Grant [FP7-IRG-239471] This study was funded from a Marie Curie Reintegration Grant (FP7-IRG-239471) to S.K. We would like to thank Prof. iskender Yilgor for allowing us to use the goniometer for WCA measurements, and Natali Cizmeciyan for providing assistance with the UV light applications. SEM experiments were performed at Koc University Surface Science Center (KUYTAM). We thank Dr Tugba Bagci Onder at School of Medicine at Koc University for providing human fibroblast cells.
dc.description.volume11
dc.identifier.doi10.1016/j.actbio.2014.09.018
dc.identifier.eissn1878-7568
dc.identifier.issn1742-7061
dc.identifier.scopus2-s2.0-84925046800
dc.identifier.urihttps://doi.org/10.1016/j.actbio.2014.09.018
dc.identifier.urihttps://hdl.handle.net/20.500.14288/10099
dc.identifier.wos347747900015
dc.keywordsPH-responsive
dc.keywordsVisible-light-induced P(MAA-g-EG) hydrogel
dc.keywordsHydrogel composite
dc.keywordsControlled drug release
dc.keywordsPregabalin
dc.language.isoeng
dc.publisherElsevier Sci Ltd
dc.relation.ispartofActa Biomaterialia
dc.subjectEngineering
dc.subjectBiomedical engineering
dc.subjectMaterials science
dc.subjectBiomaterials
dc.titleVisible-light-induced synthesis of pH-responsive composite hydrogels for controlled delivery of the anticonvulsant drug pregabalin
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorÇevik, Özlem
local.contributor.kuauthorGidon, Doğan
local.contributor.kuauthorKızılel, Seda
local.publication.orgunit1College of Engineering
local.publication.orgunit2Department of Chemical and Biological Engineering
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