Publication: Visible-light-induced synthesis of pH-responsive composite hydrogels for controlled delivery of the anticonvulsant drug pregabalin
dc.contributor.department | Department of Chemical and Biological Engineering | |
dc.contributor.kuauthor | Gidon, Doğan | |
dc.contributor.kuauthor | Kızılel, Seda | |
dc.contributor.kuauthor | Çevik, Özlem | |
dc.contributor.schoolcollegeinstitute | College of Engineering | |
dc.date.accessioned | 2024-11-09T23:14:07Z | |
dc.date.issued | 2015 | |
dc.description.abstract | We report here a novel method for the synthesis of a pH-responsive composite using visible light. Formation of the pH-responsive layer is based on poly(methacrylic acid-g-ethylene glycol) as the macromer, eosin Y as the photoinitiator and triethanolamine as the co-initiator. The hydrogel was functionalized with hydrophobic domains through incorporation of crosslinked styrene-butadiene-styrene (SBS) copolymer into the pH-responsive prepolymer. Swelling ratios were decreased with the addition of SBS, and resulted in high hydrogel crosslink density. The composite allowed for controlled release of an anticonvulsant model drug, pregabalin, under neutral pH condition and the release was analyzed to describe the mode of transport through the network. In vitro human fibroblast survival assay and in vivo rabbit implantation experiments demonstrated that this hybrid network is not toxic and has desirable biocompatibility properties. This is the first report about the synthesis of a pH-responsive network incorporating crosslinked SBS synthesized under visible light. The approach for multifunctional membranes could allow the incorporation of molecules with specific functionalities so that sequential molecule delivery in response to specific stimuli could be achieved. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.openaccess | NO | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | EU | |
dc.description.sponsorship | Marie Curie Reintegration Grant [FP7-IRG-239471] This study was funded from a Marie Curie Reintegration Grant (FP7-IRG-239471) to S.K. We would like to thank Prof. iskender Yilgor for allowing us to use the goniometer for WCA measurements, and Natali Cizmeciyan for providing assistance with the UV light applications. SEM experiments were performed at Koc University Surface Science Center (KUYTAM). We thank Dr Tugba Bagci Onder at School of Medicine at Koc University for providing human fibroblast cells. | |
dc.description.volume | 11 | |
dc.identifier.doi | 10.1016/j.actbio.2014.09.018 | |
dc.identifier.eissn | 1878-7568 | |
dc.identifier.issn | 1742-7061 | |
dc.identifier.scopus | 2-s2.0-84925046800 | |
dc.identifier.uri | https://doi.org/10.1016/j.actbio.2014.09.018 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/10099 | |
dc.identifier.wos | 347747900015 | |
dc.keywords | PH-responsive | |
dc.keywords | Visible-light-induced P(MAA-g-EG) hydrogel | |
dc.keywords | Hydrogel composite | |
dc.keywords | Controlled drug release | |
dc.keywords | Pregabalin | |
dc.language.iso | eng | |
dc.publisher | Elsevier Sci Ltd | |
dc.relation.ispartof | Acta Biomaterialia | |
dc.subject | Engineering | |
dc.subject | Biomedical engineering | |
dc.subject | Materials science | |
dc.subject | Biomaterials | |
dc.title | Visible-light-induced synthesis of pH-responsive composite hydrogels for controlled delivery of the anticonvulsant drug pregabalin | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Çevik, Özlem | |
local.contributor.kuauthor | Gidon, Doğan | |
local.contributor.kuauthor | Kızılel, Seda | |
local.publication.orgunit1 | College of Engineering | |
local.publication.orgunit2 | Department of Chemical and Biological Engineering | |
relation.isOrgUnitOfPublication | c747a256-6e0c-4969-b1bf-3b9f2f674289 | |
relation.isOrgUnitOfPublication.latestForDiscovery | c747a256-6e0c-4969-b1bf-3b9f2f674289 | |
relation.isParentOrgUnitOfPublication | 8e756b23-2d4a-4ce8-b1b3-62c794a8c164 | |
relation.isParentOrgUnitOfPublication.latestForDiscovery | 8e756b23-2d4a-4ce8-b1b3-62c794a8c164 |