Publication: Neuroprotective effects of oleocanthal, a compound in virgin olive oil, in a rat model of traumatic brain injury
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KU Authors
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Mete, Mesut
Aydemir, IÅıl
Ćƶllü, Fatih
VatandaÅ, Gƶkhan
Gürcü, Beyhan
Duransoy, Yusuf KurtuluÅ
Taneli, Fatma
TuÄlu, Mehmet İbrahim
SelƧuki, Mehmet
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Abstract
Aim: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI).
Material and Methods: Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1 was the sham group (n=5). Group 2 was the trauma group (n=5) where rats were treated with 10 mg/kg saline intraperitoneally (IP) twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n=8) or 30 (group 4, n=8) mg/kg OC IP twice a day. For each group, brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemical methods. Results: Histopathological evaluation revealed a significant difference between Group 2 and Group 4. Biochemical findings demonstrated that the oxidative stress index was highest in Group 2 and lowest in Group 4. Conclusion: OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress and apoptosis.
Source
Publisher
Turkish Neurosurgical Soc
Subject
Clinical neuropsychology, Surgery
Citation
Has Part
Source
Turkish Neurosurgery
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DOI
10.5137/1019-5149.JTN.21417-17.2