Publication:
Neuroprotective effects of oleocanthal, a compound in virgin olive oil, in a rat model of traumatic brain injury

Placeholder

Departments

School / College / Institute

Organizational Unit
Organizational Unit
SCHOOL OF MEDICINE
Upper Org Unit

Program

KU Authors

Co-Authors

Mete, Mesut
Aydemir, Işıl
Ƈƶllü, Fatih
Vatandaş, Gökhan
Gürcü, Beyhan
Duransoy, Yusuf Kurtuluş
Taneli, Fatma
Tuğlu, Mehmet İbrahim
SelƧuki, Mehmet

Publication Date

Language

Embargo Status

Journal Title

Journal ISSN

Volume Title

Alternative Title

Abstract

Aim: To evaluate the neuroprotective effects of deocanthal OC in a rat model of traumatic brain injury (TBI). Material and Methods: Twenty-six adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1 was the sham group (n=5). Group 2 was the trauma group (n=5) where rats were treated with 10 mg/kg saline intraperitoneally (IP) twice a day. Groups 3 and 4, rats were treated with 10 (group 3, n=8) or 30 (group 4, n=8) mg/kg OC IP twice a day. For each group, brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemical methods. Results: Histopathological evaluation revealed a significant difference between Group 2 and Group 4. Biochemical findings demonstrated that the oxidative stress index was highest in Group 2 and lowest in Group 4. Conclusion: OC has a protective effect on neural cells after TBI. This effect is achieved by reducing oxidative stress and apoptosis.

Source

Publisher

Turkish Neurosurgical Soc

Subject

Clinical neuropsychology, Surgery

Citation

Has Part

Source

Turkish Neurosurgery

Book Series Title

Edition

DOI

10.5137/1019-5149.JTN.21417-17.2

item.page.datauri

Link

Rights

Copyrights Note

Endorsement

Review

Supplemented By

Referenced By

0

Views

0

Downloads

View PlumX Details