Publication:
The predictive value of pretreatment hemoglobin-to-platelet ratio on osteoradionecrosis incidence rates of locally advanced nasopharyngeal cancer patients managed with concurrent chemoradiotherapy

dc.contributor.coauthorYilmaz, Busra
dc.contributor.coauthorSomay, Efsun
dc.contributor.coauthorTopkan, Erkan
dc.contributor.coauthorKucuk, Ahmet
dc.contributor.coauthorPehlivan, Berrin
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSelek, Uğur
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:40:24Z
dc.date.issued2023
dc.description.abstractBackground: This retrospective study aimed to investigate whether the pretreatment hemoglobin-to-platelet ratio (HPR) could predict the risk of osteoradionecrosis (ORN) in patients receiving concurrent chemoradiotherapy (C-CRT) for locally advanced nasopharyngeal carcinoma (LA-NPC).Methods: ORN cases were reported from the records of LA-NPC patients who had oral examinations before and after C-CRT. The pretreatment HPR values were calculated on the first day of C-CRT. The connection between HPR values and ORN occurrences was determined using receiver operating characteristic curve analysis. The primary endpoint was the relationship between the pretreatment HPR values and post-C-CRT ORN incidence rates, while secondary endpoints included the identification of other putative ORN risk factors.Results: We distinguished 10.9% incidences of ORN during the post-C-CRT follow-up period among 193 LA-NPC patients. The optimal cutoff for pre-C-CRT HPR was 0.48 that grouped the patients into two HPR groups with fundamentally different post-C-CRT ORN incidence rates: Group 1: HPR <= 0.48 (N = 60), and Group 2: HPR > 0.48 (N = 133). The comparative analysis indicated a significantly higher ORN incidence in HPR <= 0.48 group (30%; P < 0.001). The other factors associated with meaningfully increased ORN rates included the presence of pre-C-CRT >= 5 teeth extractions, mandibular volume receiving >= 64 Gy, post-C-CRT tooth extractions, mean mandibular dose >= 50.6 Gy, and C-CRT to tooth extraction interval > 5.5 months.Conclusion: Low pretreatment HPR levels were independently and unequivocally linked to significantly increased incidence of ORN post-C-CRT. Pre-C-CRT HPR levels may be used to estimate the incidence of ORN and be useful for taking preventive and therapeutic measures in these patients such as monitoring oral hygiene with strict follow-up, avoidance of unnecessary tooth extractions, particularly after C-CRT, and use of more rigorous mandibular RT dose limits.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessgold, Green Published
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume23
dc.identifier.doi10.1186/s12903-023-02937-9
dc.identifier.issn1472-6831
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85153435254
dc.identifier.urihttps://doi.org/10.1186/s12903-023-02937-9
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23301
dc.identifier.wos978680400005
dc.keywordsOsteoradionecrosis
dc.keywordsNasopharyngeal cancer
dc.keywordsHemoglobin-to-platelet ratio
dc.keywordsConcurrent chemoradiotherapy
dc.keywordsHead and neck cancer
dc.language.isoeng
dc.publisherBMC
dc.relation.ispartofBMC Oral Health
dc.subjectDentistry
dc.subjectOral surgery
dc.subjectMedicine
dc.titleThe predictive value of pretreatment hemoglobin-to-platelet ratio on osteoradionecrosis incidence rates of locally advanced nasopharyngeal cancer patients managed with concurrent chemoradiotherapy
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorSelek, Uğur
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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