Publication:
Bioactive ZnO coatings deposited by MAPLE-an appropriate strategy to produce efficient anti-biofilm surfaces

dc.contributor.coauthorOprea, Alexandra Elena
dc.contributor.coauthorPandel, Loredana Mihaela
dc.contributor.coauthorDumitrescu, Ana Maria
dc.contributor.coauthorAndronescu, Ecaterina
dc.contributor.coauthorGrumezescu, Valentina
dc.contributor.coauthorChifiriuc, Mariana Carmen
dc.contributor.coauthorMogoanta, Laurentiu
dc.contributor.coauthorBalseanu, Tudor-Adrian
dc.contributor.coauthorMogosanu, George Dan
dc.contributor.coauthorSocol, Gabriel
dc.contributor.coauthorGrumezescu, Alexandru Mihai
dc.contributor.coauthorIordache, Florin
dc.contributor.coauthorManiu, Horia
dc.contributor.coauthorHolban, Alina Maria
dc.contributor.departmentDepartment of Electrical and Electronics Engineering
dc.contributor.kuauthorChirea, Mariana
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.date.accessioned2024-11-09T11:38:10Z
dc.date.issued2016
dc.description.abstractDeposition of bioactive coatings composed of zinc oxide, cyclodextrin and cefepime (ZnO/CD/Cfp) was performed by the Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. The obtained nanostructures were characterized by X-ray diffraction, IR microscopy and scanning electron microscopy. The efficient release of cefepime was correlated with an increased anti-biofilm activity of ZnO/CD/Cfp composites. In vitro and in vivo tests have revealed a good biocompatibility of ZnO/CD/Cfp coatings, which recommend them as competitive candidates for the development of antimicrobial surfaces with biomedical applications. The release of the fourth generation cephalosporin Cfp in a biologically active form from the ZnO matrix could help preventing the bacterial adhesion and the subsequent colonization and biofilm development on various surfaces, and thus decreasing the risk of biofilm-related infections.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipRomanian National Authority for Scientific Research and Innovation, CNCS-UEFISCDI
dc.description.sponsorshipEuropean Union (EU)
dc.description.versionPublisher version
dc.description.volume21
dc.identifier.doi10.3390/molecules21020220
dc.identifier.eissn1420-3049
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR00533
dc.identifier.issn1420-3049
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-84964523355
dc.identifier.urihttps://hdl.handle.net/20.500.14288/114
dc.identifier.wos371895900042
dc.keywordsCyclodextrins
dc.keywordsZinc oxide
dc.keywordsDrug delivery
dc.keywordsMaple
dc.keywordsModified surface
dc.keywordsBiofilm inhibition
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.grantnoPN-II-RU-TE-2014-4-2269
dc.relation.grantnoPOSCCE-A2-O2.2.1-2013-1/Priority direction 2, 638/12.03.2014, SMIS-CSNR 48652
dc.relation.ispartofMolecules
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/689
dc.subjectOrganic chemistry
dc.titleBioactive ZnO coatings deposited by MAPLE-an appropriate strategy to produce efficient anti-biofilm surfaces
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorChirea, Mariana
local.publication.orgunit1College of Engineering
local.publication.orgunit2Department of Electrical and Electronics Engineering
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relation.isOrgUnitOfPublication.latestForDiscovery21598063-a7c5-420d-91ba-0cc9b2db0ea0
relation.isParentOrgUnitOfPublication8e756b23-2d4a-4ce8-b1b3-62c794a8c164
relation.isParentOrgUnitOfPublication.latestForDiscovery8e756b23-2d4a-4ce8-b1b3-62c794a8c164

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