Publication: Bioactive ZnO coatings deposited by MAPLE-an appropriate strategy to produce efficient anti-biofilm surfaces
dc.contributor.coauthor | Oprea, Alexandra Elena | |
dc.contributor.coauthor | Pandel, Loredana Mihaela | |
dc.contributor.coauthor | Dumitrescu, Ana Maria | |
dc.contributor.coauthor | Andronescu, Ecaterina | |
dc.contributor.coauthor | Grumezescu, Valentina | |
dc.contributor.coauthor | Chifiriuc, Mariana Carmen | |
dc.contributor.coauthor | Mogoanta, Laurentiu | |
dc.contributor.coauthor | Balseanu, Tudor-Adrian | |
dc.contributor.coauthor | Mogosanu, George Dan | |
dc.contributor.coauthor | Socol, Gabriel | |
dc.contributor.coauthor | Grumezescu, Alexandru Mihai | |
dc.contributor.coauthor | Iordache, Florin | |
dc.contributor.coauthor | Maniu, Horia | |
dc.contributor.coauthor | Holban, Alina Maria | |
dc.contributor.department | Department of Electrical and Electronics Engineering | |
dc.contributor.kuauthor | Chirea, Mariana | |
dc.contributor.schoolcollegeinstitute | College of Engineering | |
dc.date.accessioned | 2024-11-09T11:38:10Z | |
dc.date.issued | 2016 | |
dc.description.abstract | Deposition of bioactive coatings composed of zinc oxide, cyclodextrin and cefepime (ZnO/CD/Cfp) was performed by the Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. The obtained nanostructures were characterized by X-ray diffraction, IR microscopy and scanning electron microscopy. The efficient release of cefepime was correlated with an increased anti-biofilm activity of ZnO/CD/Cfp composites. In vitro and in vivo tests have revealed a good biocompatibility of ZnO/CD/Cfp coatings, which recommend them as competitive candidates for the development of antimicrobial surfaces with biomedical applications. The release of the fourth generation cephalosporin Cfp in a biologically active form from the ZnO matrix could help preventing the bacterial adhesion and the subsequent colonization and biofilm development on various surfaces, and thus decreasing the risk of biofilm-related infections. | |
dc.description.fulltext | YES | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 2 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | EU | |
dc.description.sponsorship | Romanian National Authority for Scientific Research and Innovation, CNCS-UEFISCDI | |
dc.description.sponsorship | European Union (EU) | |
dc.description.version | Publisher version | |
dc.description.volume | 21 | |
dc.identifier.doi | 10.3390/molecules21020220 | |
dc.identifier.eissn | 1420-3049 | |
dc.identifier.embargo | NO | |
dc.identifier.filenameinventoryno | IR00533 | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.quartile | Q2 | |
dc.identifier.scopus | 2-s2.0-84964523355 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/114 | |
dc.identifier.wos | 371895900042 | |
dc.keywords | Cyclodextrins | |
dc.keywords | Zinc oxide | |
dc.keywords | Drug delivery | |
dc.keywords | Maple | |
dc.keywords | Modified surface | |
dc.keywords | Biofilm inhibition | |
dc.language.iso | eng | |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | |
dc.relation.grantno | PN-II-RU-TE-2014-4-2269 | |
dc.relation.grantno | POSCCE-A2-O2.2.1-2013-1/Priority direction 2, 638/12.03.2014, SMIS-CSNR 48652 | |
dc.relation.ispartof | Molecules | |
dc.relation.uri | http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/689 | |
dc.subject | Organic chemistry | |
dc.title | Bioactive ZnO coatings deposited by MAPLE-an appropriate strategy to produce efficient anti-biofilm surfaces | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Chirea, Mariana | |
local.publication.orgunit1 | College of Engineering | |
local.publication.orgunit2 | Department of Electrical and Electronics Engineering | |
relation.isOrgUnitOfPublication | 21598063-a7c5-420d-91ba-0cc9b2db0ea0 | |
relation.isOrgUnitOfPublication.latestForDiscovery | 21598063-a7c5-420d-91ba-0cc9b2db0ea0 | |
relation.isParentOrgUnitOfPublication | 8e756b23-2d4a-4ce8-b1b3-62c794a8c164 | |
relation.isParentOrgUnitOfPublication.latestForDiscovery | 8e756b23-2d4a-4ce8-b1b3-62c794a8c164 |
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