Publication:
AI-assisted optoelectrokinetic control of active self-propelling micromotors for independent navigation with multimode motions

dc.contributor.coauthorLiu, J.
dc.contributor.coauthorZheng, Z.
dc.contributor.coauthorHou, Y.
dc.contributor.coauthorShi, Q.
dc.contributor.coauthorHuang, Q.
dc.contributor.coauthorHan, J.
dc.contributor.coauthorWang, H.
dc.contributor.departmentSchool of Medicine
dc.contributor.departmentDepartment of Mechanical Engineering
dc.contributor.kuauthorSitti, Metin
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.date.accessioned2026-09-15T10:56:24Z
dc.date.issued2026
dc.description.abstractAgile and controllable motion is essential for active micromotors to navigate various microscale scenarios and manipulate the microscopic world, where parallel navigation and independent control are highly desirable. However, most micromotor navigation strategies suffer from limited agility and poor predictability, with motion typically confined to single-micromotor self-propulsion along predetermined trajectories. Herein, we propose an artificial intelligence (AI)–assisted optoelectronic control strategy that involves converting stochastic micromotor self-propulsion into controllable omnidirectional motion by synergistically exploiting multiple electrokinetic mechanisms. This strategy enables independent navigation of individual micromotors while simultaneously supporting parallel manipulation. By spatiotemporally configuring two or more optical patterns, agile motion primitives, such as directional propulsion, passive propulsion, in situ U-turns, and motion pause and restarting, were developed. To improve navigation robustness under coupled electrokinetic effects, a spatial-temporal AI model was developed for accurately predicting micromotor motion to facilitate the optimization of dynamic guidance schemes. These motion primitives are sequentially integrated and automatedly switched along long-term, reconfigurable trajectories, thereby enabling continuous navigation guided by discrete optical patterns. Independent control of active micromotors was demonstrated through the parallel manipulation of multiple Janus micromotors that were navigating intricate networks, in which each micromotor followed individual trajectories and adapted in real time to local terrain variations. This work showcased an agile and predictable navigation strategy for active micromotors that facilitates independent and massively parallel manipulation in intricate terrains, thus opening further possibilities for advanced applications.
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipNational Natural Science Foundation of China (Grant: 62403056); National Natural Science Foundation of China (Grant: 62573060); Fundamental Research Funds for the Central Universities (Grant: 2025CX01003); National Key Research and Development Program of China (Grant: 2023YFB4705400); Beijing Natural Science Foundation (Grant: L242023) [Funding]: This work was supported by the National Natural Science Foundation of China under grant number 62573060 (H.W.), National Natural Science Foundation of China under grant number 62403056 (Y.H.), Beijing Natural Science Foundation under grant L242023 (H.W.), and Fundamental Research Funds for the Central Universities under grant 2025CX01003 (H.W.). [Acknowledgements]: We thank C. Li and Z. Li for assistance in active micromotor fabrication. Funding: This work was supported by the National Natural Science Foundation of China under grant number 62573060 (H.W.), National Natural Science Foundation of China under grant number 62403056 (Y.H.), Beijing Natural Science Foundation under grant L242023 (H.W.), and Fundamental Research Funds for the Central Universities under grant 2025CX01003 (H.W.). Author contributions: Conceptualization: J.L. and Z.Z. Methodology: J.L. and Z.Z. Investigation: J.L., Z.Z., Q.S., and Q.H. Funding acquisition: H.W. and M.S. Supervision: H.W., M.S., Q.S., and Q.H. Writing—original draft: J.L., Z.Z., J.H., H.W., and M.S. Writing—review and editing: Y.H., H.W., and M.S. Competing interests: The authors declare that they have no competing interests. Data, code, and materials availability: All data needed to evaluate and reproduce the results in the paper are present in the paper and/or the Supplementary Materials. The source code is fully available at https://github.com/husandaimei/ResNet-Transformer-for-motion-prediction.git and https://doi.org/10.5281/zenodo.19245390 . This study did not generate new materials.
dc.description.versionPublished Version
dc.identifier.ScopusPercentile96
dc.identifier.ScopusQuartileQ1
dc.identifier.WoSPercentile91.8
dc.identifier.WoSQuartileQ1
dc.identifier.doi10.1126/sciadv.aef0741
dc.identifier.eissn2375-2548
dc.identifier.endpage-
dc.identifier.grantno62403056
dc.identifier.grantno62573060
dc.identifier.grantno2025CX01003
dc.identifier.grantno2023YFB4705400
dc.identifier.grantnoL242023
dc.identifier.issn2375-2548
dc.identifier.issue33
dc.identifier.pubmed42600016
dc.identifier.scopus2-s2.0-105047563716
dc.identifier.startpage-
dc.identifier.urihttp://doi.org/10.1126/sciadv.aef0741
dc.identifier.urihttps://hdl.handle.net/20.500.14288/35499
dc.identifier.volume12
dc.keywordsMicroscale chemistry
dc.keywordsMotion control
dc.keywordsMotion planning
dc.keywordsRobustness (evolution)
dc.keywordsRoaming
dc.keywordsMotion (physics)
dc.keywordsElectrokinetic phenomena
dc.keywordsTrajectory
dc.languageeng
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofScience Advances
dc.relation.openaccessN/A
dc.subjectPhysical sciences
dc.subjectPhysics and astronomy
dc.subjectCondensed matter physics
dc.subjectEngineering
dc.subjectBiomedical engineering
dc.subjectMechanical engineering
dc.titleAI-assisted optoelectrokinetic control of active self-propelling micromotors for independent navigation with multimode motions
dc.typeJournal Article
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