Publication:
Unveiling the intricacies of chronic kidney disease: from ocular manifestations to therapeutic frontiers

dc.contributor.coauthorMallamaci, Francesca
dc.contributor.coauthorZoccali, Carmine
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorÇöpür, Sidar
dc.contributor.kuauthorGüldan, Mustafa
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuauthorÖzbek, Laşin
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T20:58:09Z
dc.date.issued2025
dc.description.abstractBackground Shared anatomical, histological and physiological pathways between the kidney and the eye are well documented, demonstrating that ocular manifestations serve as valuable prognostic indicators in chronic kidney disease (CKD), providing insights into disease severity and progression. Through non-invasive imaging modalities such as retinal fundus photography, early retinal microvascular alterations indicative of CKD progression can be detected, enabling timely intervention and risk stratification. However, the conclusions drawn from the review primarily demonstrate a strong or independent association between glaucoma or retinopathy and CKD. Results and Conclusion Multiple shared pathophysiological events have been implicated in the pathogenesis in the alterations at eye and kidney including renin-angiotensin-aldosterone system. Patients with CKD are more likely to experience glaucoma, age-related macular degeneration, cataracts, uremic optic neuropathy and retinopathy. To establish the role of ocular manifestations in predicting CKD progression, it is crucial to address the limitations of correlation and explore the underlying causality with further research on common disease pathogenesis. Additionally, specific methods for risk stratification based on retinal changes, the effectiveness of timely interventions, and the development of predictive tools combining ocular and renal data are of utmost importance research topics to enlighten the bidirectional causality.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.1111/eci.14324
dc.identifier.eissn1365-2362
dc.identifier.issn0014-2972
dc.identifier.issue1
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85205071444
dc.identifier.urihttps://doi.org/10.1111/eci.14324
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27394
dc.identifier.volume55
dc.identifier.wos1320838400001
dc.keywordsChronic kidney disease
dc.keywordsEnd-stage kidney disease
dc.keywordsGlaucoma
dc.keywordsImaging modalities
dc.keywordsOcular manifestations
dc.keywordsRetinopathy
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofEUROPEAN JOURNAL OF CLINICAL INVESTIGATION
dc.subjectMedicine
dc.titleUnveiling the intricacies of chronic kidney disease: from ocular manifestations to therapeutic frontiers
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorKanbay, Mehmet
local.contributor.kuauthorGüldan, Mustafa
local.contributor.kuauthorÖzbek, Laşin
local.contributor.kuauthorÇöpür, Sidar
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
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