Publication:
Comparison of Ampullary and Pancreatic Adenocarcinomas: Smaller Invasion, Common Adenomatous Components, Resectability, and Histology are Factors for Improved Survival for Patients with Ampullary Adenocarcinoma

dc.contributor.coauthorMemis, Bahar
dc.contributor.coauthorPehlivanoglu, Burcin
dc.contributor.coauthorKim, Grace
dc.contributor.coauthorBalci, Serdar
dc.contributor.coauthorTajiri, Takuma
dc.contributor.coauthorOhike, Nobuyuki
dc.contributor.coauthorBagci, Pelin
dc.contributor.coauthorAkar, Kadriye Ebru
dc.contributor.coauthorMuraki, Takashi
dc.contributor.coauthorJang, Kee-Taek
dc.contributor.coauthorMaithel, Shishir K.
dc.contributor.coauthorSarmiento, Juan
dc.contributor.coauthorKooby, David A.
dc.contributor.coauthorTarcan, Zeynep Cagla
dc.contributor.coauthorGoodman, Michael
dc.contributor.coauthorXue, Yue
dc.contributor.coauthorKrasinskas, Alyssa
dc.contributor.coauthorReid, Michelle
dc.contributor.coauthorBasturk, Olca
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAdsay, Nazmi Volkan
dc.contributor.kuauthorEsmer, Rohat
dc.contributor.kuauthorSaka, Burcu
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T20:57:26Z
dc.date.issued2024
dc.description.abstractBackground. The information on the clinicopathologic/outcome differences between ampullary adenocarcinoma (AC) and pancreatic adenocarcinoma (PC) has been conflicting to the extent that it still is questioned whether ACs need to be recognized separately from PCs. Methods. The characteristics of 413 ACs were compared with those of 547 PCs. Results. The ACs had a better prognosis than the PCs (5-year survival, 57 % vs 23 %;p < 0.001). Even the pancreatobiliary (PB)-type ACs had a better prognosis (5-year survival, 46 % vs 23 %;p < 0.001). Several differences also were identified as contributing factors: (1) the preinvasive adenomatous component often constituted a significant proportion of the mass in ACs (>50 % of the tumor in 16 % vs 1.5 %;p < 0.001);(2) the mean size of the carcinoma was smaller in ACs (2.5 vs 3.2 cm;p < 0.001): when matched for invasion size, the survival advantage of AC was minimized, and when matched for invasion size larger than 2 cm, the survival advantage of AC lost its statistical significance;(3) lymph node (LN) metastases were less common in ACs (49 % vs 71 %;p < 0.001);(4) the definitive R1 rate was lower in ACs (4 % vs 23.5 %;p < 0.001);and (5) non-PB and non-tubular adenocarcinoma types were more common in ACs (17 % vs 3 %;p < 0.001). Conclusions. Comparatively, ACs have better clinical survival than PCs. Potential contributing factors are the relative abundance of the preinvasive component, smaller invasion, lower LN metastasis rate, higher resectability, and common occurrence of less aggressive histologic phenotypes (intestinal, medullary, mucinous). However, this survival advantage is sustained even in PB-type ACs, highlighting the importance of accurately determining the site of origin.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipOlca Basturk is supported in part by the Cancer Center Support Grant of the National Institutes of Health/National Cancer Institute under award number P30CA008748.
dc.identifier.doi10.1245/s10434-024-16355-w
dc.identifier.eissn1534-4681
dc.identifier.grantnoCancer Center Support Grant of the National Institutes of Health/National Cancer Institute [P30CA008748]
dc.identifier.issn1068-9265
dc.identifier.issue3
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85206688099
dc.identifier.urihttps://doi.org/10.1245/s10434-024-16355-w
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27235
dc.identifier.volume32
dc.identifier.wos1336736200003
dc.keywordsAmpulla
dc.keywordsPancreas
dc.keywordsCarcinoma
dc.keywordsStage
dc.keywordsHistologic phenotype
dc.keywordsSize
dc.keywordsMetastasis
dc.keywordsSurvival
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofANNALS OF SURGICAL ONCOLOGY
dc.subjectOncology
dc.subjectSurgery
dc.titleComparison of Ampullary and Pancreatic Adenocarcinomas: Smaller Invasion, Common Adenomatous Components, Resectability, and Histology are Factors for Improved Survival for Patients with Ampullary Adenocarcinoma
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAdsay, Nazmi Volkan
local.contributor.kuauthorSaka, Burcu
local.contributor.kuauthorEsmer, Rohat
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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