Publication:
Tissue-like optoelectronic neural interface enabled by PEDOT:PSS hydrogel for cardiac and neural stimulation

dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentDepartment of Electrical and Electronics Engineering
dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.departmentSchool of Medicine
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.kuauthorHan, Mertcan
dc.contributor.kuauthorKaraz, Selcan
dc.contributor.kuauthorEren, Güncem Özgün
dc.contributor.kuauthorDoğru-Yüksel, Itır Bakış
dc.contributor.kuauthorYıldız, Erdost
dc.contributor.kuauthorKaleli, Humeyra Nur
dc.contributor.kuauthorŞenses, Erkan
dc.contributor.kuauthorŞahin, Afsun
dc.contributor.kuauthorNizamoğlu, Sedat
dc.contributor.kuprofileMaster Student
dc.contributor.kuprofileMaster Student
dc.contributor.kuprofilePhD Student
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.yokidN/A
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dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokidN/A
dc.contributor.yokid280298
dc.contributor.yokid171267
dc.contributor.yokid130295
dc.date.accessioned2024-11-09T13:08:55Z
dc.date.issued2022
dc.description.abstractOptoelectronic biointerfaces have made a significant impact on modern science and technology from understanding the mechanisms of the neurotransmission to the recovery of the vision for blinds. They are based on the cell interfaces made of organic or inorganic materials such as silicon, graphene, oxides, quantum dots, and ?-conjugated polymers, which are dry and stiff unlike a cell/tissue environment. On the other side, wet and soft hydrogels have recently been started to attract significant attention for bioelectronics because of its high-level tissue-matching biomechanics and biocompatibility. However, it is challenging to obtain optimal opto-bioelectronic devices by using hydrogels requiring device, heterojunction, and hydrogel engineering. Here, an optoelectronic biointerface integrated with a poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate), PEDOT:PSS, hydrogel that simultaneously achieves efficient, flexible, stable, biocompatible, and safe photostimulation of cells is demonstrated. Besides their interfacial tissue-like biomechanics, ?34 kPa, and high-level biocompatibility, hydrogel-integration facilitates increase in charge injection amounts sevenfolds with an improved responsivity of 156 mA W?1, stability under mechanical bending , and functional lifetime over three years. Finally, these devices enable stimulation of individual hippocampal neurons and photocontrol of beating frequency of cardiac myocytes via safe charge-balanced capacitive currents. Therefore, hydrogel-enabled optoelectronic biointerfaces hold great promise for next-generation wireless neural and cardiac implants.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue8
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipEuropean Union (EU)
dc.description.sponsorshipHorizon 2020
dc.description.sponsorshipEuropean Research Council (ERC)
dc.description.sponsorshipResearch and Innovation Programme
dc.description.sponsorshipTurkish Academy of Sciences (TÜBA-GEBIP) The Young Scientist Award Program
dc.description.sponsorshipScience Academy of Turkey (BAGEP) The Young Scientist Award Program
dc.description.sponsorshipBilim Kahramanları Derneği The Young Scientist Award Program
dc.description.versionAuthor's final manuscript
dc.description.volume11
dc.formatpdf
dc.identifier.doi10.1002/adhm.202102160
dc.identifier.eissn2192-2659
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03713
dc.identifier.issn2192-2640
dc.identifier.linkhttps://doi.org/10.1002/adhm.202102160
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85122708580
dc.identifier.urihttps://hdl.handle.net/20.500.14288/2722
dc.identifier.wos742952000001
dc.keywordsBioelectronic
dc.keywordsBiointerfaces
dc.keywordsCardiac stimulation
dc.keywordsCell stimulation
dc.keywordsHydro-gels
dc.keywordsNeuromodulation
dc.keywordsOptoelectronics
dc.languageEnglish
dc.publisherWiley
dc.relation.grantno639846
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10571
dc.sourceAdvanced Healthcare Materials
dc.titleTissue-like optoelectronic neural interface enabled by PEDOT:PSS hydrogel for cardiac and neural stimulation
dc.typeJournal Article
dspace.entity.typePublication
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local.contributor.kuauthorHan, Mertcan
local.contributor.kuauthorKaraz, Selcan
local.contributor.kuauthorEren, Güncem Özgün
local.contributor.kuauthorDoğru-Yüksel, Itır Bakış
local.contributor.kuauthorYıldız, Erdost
local.contributor.kuauthorKaleli, Humeyra Nur
local.contributor.kuauthorŞenses, Erkan
local.contributor.kuauthorŞahin, Afsun
local.contributor.kuauthorNizamoğlu, Sedat
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
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local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2Department of Electrical and Electronics Engineering
local.publication.orgunit2Department of Chemical and Biological Engineering
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Sciences and Engineering
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