Publication:
Effect of nasal corticosteroid on secretory immunoglobulin a measured in rat nasal lavage: experimental study

dc.contributor.coauthorAksoy, Fadlullah
dc.contributor.coauthorDogan, Remzi
dc.contributor.coauthorVeyseller, Bayram
dc.contributor.coauthorOzturan, Orhan
dc.contributor.coauthorIncir, Said
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.kuauthorKoçak, İlker
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.date.accessioned2024-11-09T22:51:46Z
dc.date.issued2015
dc.description.abstractObjective In this study, we aimed to experimentally investigate the effects of nasal corticosteroids on the levels of secretory immunoglobulin A (sIgA) in nasal mucosa in rats. Study Design Prospective, randomized control trial. Setting Research laboratory. Subject and Methods Twenty-four male Sprague Dawley rats were included in our study. The rats were randomized into 3 groups. In group 1, nasal mometasone furoate was applied to the rats for 30 days. Saline was applied to group 2 for 30 days. Group 3 was the control group and received no treatment throughout the study period. Nasal lavage was conducted on both nasal openings of all rats in the 3 groups at the beginning of the study and on days 15 and 30, and the lavage solution (distilled water) was collected by aspiration. Results In group 1, the sIgA value was significantly higher at day 15 than at baseline. No significant difference was found between the sIgA values on day 15 and day 30. In groups 2 and 3, there were no significant differences in sIgA values at baseline, day 15, and day 30. The sIgA value of group 1 on day 15 was significantly higher than the values of groups 2 and 3. The sIgA value of group 1 on day 30 was significantly higher than the values of groups 2 and 3. Conclusion Topical corticosteroids (mometasone furoate) applied to the nasal mucosa significantly increase nasal sIgA levels.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume153
dc.identifier.doi10.1177/0194599815589073
dc.identifier.eissn1097-6817
dc.identifier.issn0194-5998
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-84937723489
dc.identifier.urihttps://doi.org/10.1177/0194599815589073
dc.identifier.urihttps://hdl.handle.net/20.500.14288/6902
dc.identifier.wos358387000024
dc.keywordsMometasone furoate
dc.keywordsNasal lavage
dc.keywordsRat
dc.keywordsSecretory immunoglobulin
dc.keywordsA mometasone furoate
dc.keywordsIntranasal use
dc.keywordsInflammation
dc.keywordsInduction
dc.keywordsRhinitis
dc.keywordsSpray
dc.language.isoeng
dc.publisherSage
dc.relation.ispartofOtolaryngology-Head and Neck Surgery
dc.subjectOtorhinolaryngology
dc.subjectSurgery
dc.titleEffect of nasal corticosteroid on secretory immunoglobulin a measured in rat nasal lavage: experimental study
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKoçak, İlker
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
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