Publication:
The pathophysiology and management of vascular calcification in chronic kidney disease patients

dc.contributor.coauthorGalassi, Andrea
dc.contributor.coauthorCiceri, Paola
dc.contributor.coauthorCozzolino, Mario
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorÇöpür, Sidar
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuauthorTanrıöver, Cem
dc.contributor.kuauthorYavuz, Furkan
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:07:54Z
dc.date.issued2023
dc.description.abstractIntroductionVascular calcification (VC) which is the pathological mineral deposition in the vascular system, predominantly at the intimal and medial layer of the vessel wall, is an important comorbidity in patients with chronic kidney disease (CKD) leading to significant morbidity and mortality while necessitating appropriate treatment. Our review aims to provide an in-depth analysis of the current understanding of VC.Areas coveredIn this review, we first discuss the pathophysiology of VC in CKD patients, then we explain the methods to predict and assess VC. Afterwards, we provide the currently available as well as the potential therapeutic approaches of VC. We finally discuss our understanding regarding the current situation surrounding VC in our expert opinion section.Expert opinionPredicting, assessing and treating VC is crucial and the future advances in the field of research surrounding VC will potentially occur in one or more of these three areas of clinical management. There is a current lack of evidence and consensus regarding specific therapeutic options for alleviating VC and this situation may not necessitate VC to be determined, detected, and documented before the available options are implemented. Regardless, the prediction and assessment of VC is still important and requires further improvement together with the developments in therapeutic alternatives. The future has the potential to bring better research which would guide and improve the management of this patient group. A more specialized approach consisting of targeted therapies and more tailored management plans for patients with CKD and VC is on the horizon.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume21
dc.identifier.doi10.1080/14779072.2023.2174525
dc.identifier.eissn1744-8344
dc.identifier.issn1477-9072
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85147577080
dc.identifier.urihttps://doi.org/10.1080/14779072.2023.2174525
dc.identifier.urihttps://hdl.handle.net/20.500.14288/9226
dc.identifier.wos923787300001
dc.keywordsVascular calcification
dc.keywordsChronic kidney disease
dc.keywordsIntimal calcification
dc.keywordsTherapeutics
dc.language.isoeng
dc.publisherTaylor & Francis
dc.relation.ispartofExpert Review of Cardiovascular Therapy
dc.subjectCardiac
dc.subjectCardiovascular systems
dc.titleThe pathophysiology and management of vascular calcification in chronic kidney disease patients
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorÇöpür, Sidar
local.contributor.kuauthorKanbay, Mehmet
local.contributor.kuauthorYavuz, Furkan
local.contributor.kuauthorTanrıöver, Cem
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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