Publication:
Delta brush pattern is not unique to NMDAR encephalitis: evaluation of two independent long-term EEG cohorts

dc.contributor.coauthorBaykan, Betül
dc.contributor.coauthorTuncer, Özlem Güngör
dc.contributor.coauthorKıraç, Leyla Baysal
dc.contributor.coauthorGündoğdu, Gökçen
dc.contributor.coauthorBebek, Nerses
dc.contributor.coauthorGürses, Candan
dc.contributor.coauthorAltındağ, Ebru
dc.contributor.coauthorTüzün, Erdem
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorVanlı-Yavuz, Ebru Nur
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:05:19Z
dc.date.issued2018
dc.description.abstractPurpose: Although its specificity has not previously been investigated in other cohorts, delta brush pattern (DBP) is increasingly reported in the EEGs of patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. Methods: We aimed to investigate the DBP in the EEGs of 2 cohorts; patients with change in consciousness for various causes monitored in the intensive care unit (ICU) (n = 106) and patients with mesial temporal lobe epilepsy (MTLE) with or without antineuronal antibodies (n = 76). Results: These patients were investigated for the presence of DBP, defined as an EEG pattern characterized by delta activity at 1 to 3 Hz with superimposed bursts of rhythmic 12- to 30-Hz activity. Two investigators blindfolded for the clinical and immunological data independently analyzed the EEGs for recognition of this pattern. An EEG picture compatible with DBP was observed in 4 patients; only 1 of them (1.3%) belonged to the MTLE group. She did not bear any of the investigated autoantibodies and was seizure-free after epilepsy surgery. In the ICU group, there were 3 additional patients showing DBP with various diagnoses such as hypoxic encephalopathy, brain tumor, stroke, and metabolic derangements. All of them had died in 1-month period. Conclusions: Our results underlined that DBP is not unique to NMDAR encephalitis; it may very rarely occur in MTLE with good prognosis after surgery and second, in ICU patients who have high mortality rate. Therefore, the presence of this pattern should alert the clinician for NMDAR encephalitis but other possible etiologies should not be ignored.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue4
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipTurkish Scientific and Technical Research Council [214S170]
dc.description.sponsorshipIstanbul University Research Fund [BAP-36854] The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Turkish Scientific and Technical Research Council (Project No. 214S170) and Istanbul University Research Fund (Project No. BAP-36854).
dc.description.volume49
dc.identifier.doi10.1177/1550059417693168
dc.identifier.eissn2169-5202
dc.identifier.issn1550-0594
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85042183749
dc.identifier.urihttps://doi.org/10.1177/1550059417693168
dc.identifier.urihttps://hdl.handle.net/20.500.14288/8772
dc.identifier.wos433534500007
dc.keywordsElectroencephalography
dc.keywordsDelta brush pattern
dc.keywordsAnti-N-methyl-d-aspartate receptor encephalitis
dc.keywordsLong-term video-EEG monitoring
dc.keywordsIntensive care unit
dc.keywordsMesial temporal lobe epilepsy
dc.language.isoeng
dc.publisherSage Publications Inc
dc.relation.ispartofClinical Eeg and Neuroscience
dc.subjectClinical neuropsychology
dc.subjectNeurosciences
dc.subjectNeuroimaging
dc.subjectPsychiatry
dc.subjectPsychology
dc.titleDelta brush pattern is not unique to NMDAR encephalitis: evaluation of two independent long-term EEG cohorts
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorVanlı-Yavuz, Ebru Nur
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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