Publication:
Analysis of clinical characteristics and factors affecting treatment responses in patients with pyoderma gangrenosum: a multicenter study of 239 patients(☆)

dc.contributor.coauthorErduran, Funda
dc.contributor.coauthorAdışen, Esra
dc.contributor.coauthorHayran, Yıldız
dc.contributor.coauthorAksoy, Güneş Gür
dc.contributor.coauthorAlpsoy, Erkan
dc.contributor.coauthorSelçuk, Leyla Baykal
dc.contributor.coauthorElmas, Leyla
dc.contributor.coauthorAydoğan, Kübra
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSaraç, Esra
dc.contributor.kuauthorYaylı, Savaş
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T20:57:24Z
dc.date.issued2024
dc.description.abstractBackground: Pyoderma Gangrenosum (PG) is a chronic disease characterized by recalcitrant skin ulcers. Objective: We aimed to evaluate the demographic, clinical characteristics, treatments and factors affecting the treatment responses of patients with PG. Methods: We performed a multicenter study of 12 tertiary care centers. We analyzed the data of the patients who were followed up with a diagnosis of PG between the years 2012-2022 retrospectively. Results: We included a total of 239 patients of whom 143 were female and 96 were male, with an average age of 54.2 +/- 17.4 years. The most common treatment was systemic steroids (n = 181, 75.7%). Among these patients, 50.8% (n = 92) used systemic steroids as the sole systemic agent, while 49.2% (n = 89) used at least one adjuvant immunosuppressive agent. The independent factors determined in regression analysis to influence response to systemic steroids positively were disease onset age >= 30-years, negative pathergy, absence of leukocytosis, negative wound culture, presence of a single lesion, and absence of upper extremity involvement. Biological agents were used in 18.4% (n = 44) of the patients in the present study. We also analyzed pathergy positive PG and early onset (onset age < 30) PG separately due to their distinct clinical features which were revealed during statistical analysis. Study limitations: Retrospective nature of the present study. Conclusions: Analyses of the factors influencing treatment responses are addressed in this study. Also, we concluded that investigation for accompanying autoinflammatory diseases of pathergy positive PG and early onset PG is necessary and the patients in these two groups are more resistant to treatment, necessitating more complicated treatments.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.1016/j.abd.2024.02.002
dc.identifier.eissn1806-4841
dc.identifier.issn0365-0596
dc.identifier.issue6
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85192513844
dc.identifier.urihttps://doi.org/10.1016/j.abd.2024.02.002
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27223
dc.identifier.volume99
dc.identifier.wos1343339900001
dc.keywordsComorbidity
dc.keywordsHereditary autoinflammatory diseases
dc.keywordsImmunosuppressive agents
dc.keywordsPyoderma gangrenosum
dc.keywordsRegression analysis
dc.language.isoeng
dc.publisherElsevier Science Ltd
dc.relation.ispartofAn Bras Dermatol
dc.subjectMedicine
dc.titleAnalysis of clinical characteristics and factors affecting treatment responses in patients with pyoderma gangrenosum: a multicenter study of 239 patients(☆)
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorYaylı, Savaş
local.contributor.kuauthorSaraç, Esra
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
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