Publication:
Endostatin in chronic kidney disease: associations with inflammation, vascular abnormalities, cardiovascular events and survival

dc.contributor.coauthorAfsar, Baris
dc.contributor.coauthorSiriopol, Dimitrie
dc.contributor.coauthorUnal, Hilmi Umut
dc.contributor.coauthorKaraman, Murat
dc.contributor.coauthorSaglam, Mutlu
dc.contributor.coauthorGezer, Mustafa
dc.contributor.coauthorTas, Ahmet
dc.contributor.coauthorEyileten, Tayfun
dc.contributor.coauthorGuler, Ahmet Kerem
dc.contributor.coauthorAydin, Ibrahim
dc.contributor.coauthorOguz, Yusuf
dc.contributor.coauthorCovic, Adrian
dc.contributor.coauthorYilmaz, Mahmut Ilker
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuauthorTarım, Kayhan
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:17:57Z
dc.date.issued2016
dc.description.abstractBackground and aims: Endostatin, generated from collagen XVIII, and endorepellin, possess dual activity as modifiers of both angiogenesis and endothelial cell autophagy. Plasma endostatin levels are elevated in a large number of diseases, and may reflect endothelial cell dysfunction. Few data on endostatins are available for patients with chronic kidney disease (CKD). We tested whether serum endostatin values are predictive for all-cause mortality and cardiovascular events (CVEs) in a CKD population. Materials and method: A total of 519 CKD pre-dialysis patients were included. Baseline plasma endostatin levels were measured in all patients. All included patients were followed-up (time-to-event analysis) until occurrence of death, fatal or nonfatal CVEs. Fatal and nonfatal CVE including death, stroke, and myocardial infarction were recorded prospectively Results: The mean age of the patients was 52.2 +/- 12.3 years. There were 241 (46.4%) males, 111 (21.4%) had diabetes, 229 (44.1%) were smokers and 103 (19.8%) had a previous CVE. After a median follow-up of 46 months, 46 patients died and 172 had a new CVE. In the univariable Cox survival analysis, higher endostatin levels were associated with a higher risk for both outcomes. However, after adjusting for traditional (age, gender, smoking status, diabetes, systolic blood pressure, HDL and total cholesterol) and renal-specific (eGFR, proteinuria and hsCRP) risk factors, endostatin levels remained associated only with the CVE outcome (HR = 1.88, 95% CI 1.37-2.41 for a 1 SD increase in log endostatin values). Conclusion: Endostatin levels are independently associated with incident CVE in CKD patients, but show limited prediction abilities for all-cause mortality and CVE above traditional and renal-specific risk factors. (C) 2016 European Federation of Internal Medicine. Published by Elsevier B.V. .
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume33
dc.identifier.doi10.1016/j.ejim.2016.06.033
dc.identifier.eissn1879-0828
dc.identifier.issn0953-6205
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-84991201458
dc.identifier.urihttps://doi.org/10.1016/j.ejim.2016.06.033
dc.identifier.urihttps://hdl.handle.net/20.500.14288/10295
dc.identifier.wos384730600028
dc.keywordsEndostatin
dc.keywordsCardiovascular events
dc.keywordsChronic kidney disease
dc.keywordsEndothelial dysfunction
dc.keywordsSerum endostatin
dc.keywordsGrowth-factor
dc.keywordsMyocardial-infarction
dc.keywordsElderly findings
dc.keywordsHeart-failure
dc.keywordsRisk
dc.keywordsModel
dc.keywordsMortality
dc.keywordsAngiogenesis
dc.keywordsDysfunction
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofEuropean Journal of Internal Medicine
dc.subjectMedicine
dc.subjectGeneral and internal medicine
dc.titleEndostatin in chronic kidney disease: associations with inflammation, vascular abnormalities, cardiovascular events and survival
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKanbay, Mehmet
local.contributor.kuauthorTarım, Kayhan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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