Publication:
GLP-1’s role in neuroprotection: a systematic review

dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorDemirel, Çağrı
dc.contributor.kuauthorErbil, Damla
dc.contributor.kuauthorEren, Candan Yasemin
dc.contributor.kuauthorEser, Hale Yapıcı
dc.contributor.kuauthorKüçüker, Mehmet Utku
dc.contributor.kuauthorSolaroğlu, İhsan
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:25:45Z
dc.date.issued2019
dc.description.abstractGlucagon-like peptide 1 (GLP-1) is a target for treatment of diabetes; however, its function in the brain is not well studied. In this systematic review, we aimed to analyze the neuroprotective role of GLP-1 and its defined mechanisms.Methods: We searched Web of Science' and Pubmed' to identify relevant studies using GLP-1 as the keyword. Two hundred and eighty-nine clinical and preclinical studies have been included. Data have been presented by grouping neurodegenerative, neurovascular and specific cell culture models.Results: Recent literature shows that GLP-1 and its agonists, DPP-4 inhibitors and combined GLP-1/GIP molecules are effective in partially or fully reversing the effects of neurotoxic compounds, neurovascular complications of diabetes, neuropathological changes related with Alzheimer's disease, Parkinson's disease or vascular occlusion. Possible mechanisms that provide neuroprotection are enhancing the viability of the neurons and restoring neurite outgrowth by increased neurotrophic factors, increasing subventricular zone progenitor cells, decreasing apoptosis, decreasing the level of pro-inflammatory factors, and strengthening blood-brain barrier.Conclusion: Based on the preclinical studies, GLP-1 modifying agents are promising targets for neuroprotection. On the other hand, the number of clinical studies that investigate GLP-1 as a treatment is low and further clinical trials are needed for a benchside to bedside translation of recent findings.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue6
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipRepublic of Turkey Ministry of Development The authors gratefully acknowledge use of the services and facilities of the Koc University Research Center for Translational Medicine (KUTTAM), funded by the Republic of Turkey Ministry of Development. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Ministry of Development.
dc.description.volume33
dc.identifier.doi10.1080/02699052.2019.1587000
dc.identifier.eissn1362-301X
dc.identifier.issn0269-9052
dc.identifier.scopus2-s2.0-85065411085
dc.identifier.urihttps://doi.org/10.1080/02699052.2019.1587000
dc.identifier.urihttps://hdl.handle.net/20.500.14288/11436
dc.identifier.wos473458900006
dc.keywordsGLP-1
dc.keywordsNeuroprotection
dc.keywordsStroke
dc.keywordsParkinson
dc.keywordsAlzheimer
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBrain Injury
dc.subjectNeurosciences
dc.subjectRehabilitation
dc.titleGLP-1’s role in neuroprotection: a systematic review
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorErbil, Damla
local.contributor.kuauthorEren, Candan Yasemin
local.contributor.kuauthorDemirel, Çağrı
local.contributor.kuauthorKüçüker, Mehmet Utku
local.contributor.kuauthorSolaroğlu, İhsan
local.contributor.kuauthorEser, Hale Yapıcı
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
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