Publication: The effect of serum C-reactive protein and ferritin levels on all-cause and cardiovascular mortality in haemodialysis patients
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KU-Authors
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Co-Authors
Siriopol, Dimitrie
Popa, Raluca
Vasiliu, Vlad
Neamtu, Andreea
Cusai, Silvia Corina
Voiculescu, Daniela Caliopi
Stuard, Stefano
Covic, Adrian
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Abstract
Background and Aims: Ferritin, is commonly used as a surrogate marker of iron storage in haemodialysis (HD) patients. However, besides being an indicator of iron storage, serum ferritin levels are closely influenced by non-iron related factors, such as systemic inflammation. The aim of this study is to assess the combined effect of serum ferritin and C-reactive protein (CRP) levels on all-cause and cardiovascular (CV) mortality in a large national cohort of HD patients. Method: This is a retrospective study which included all patients that were on standard HD therapy in 34 Romanian Fresenius dialysis units at January 1st 2014. The main outcomes were all-cause and CV mortality. Patients were censored at December 31st 2016. Results: Our study included 1255 patients. The mean age of the population at baseline was 59 years. The median values for CRP and ferritin levels were 4.8 (IQR 1.9-11.0) mg/ dL and 696.0 (IQR 448.5-996.8) ng/mL, respectively
Source
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Oxford Univ Press
Subject
Transplantation, Urology and nephrology
Citation
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Source
Nephrology Dialysis Transplantation
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DOI
10.1093/ndt/gfaa142.P1473
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